Cargando…

NT1014, a novel biguanide, inhibits ovarian cancer growth in vitro and in vivo

BACKGROUND: NT1014 is a novel biguanide and AMPK activator with a high affinity for the organic cation-specific transporters, OCT1 and OCT3. We sought to determine the anti-tumorigenic effects of NT1014 in human ovarian cancer cell lines as well as in a genetically engineered mouse model of high-gra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Lu, Han, Jianjun, Jackson, Amanda L., Clark, Leslie N., Kilgore, Joshua, Guo, Hui, Livingston, Nick, Batchelor, Kenneth, Yin, Yajie, Gilliam, Timothy P., Gehrig, Paola A., Sheng, Xiugui, Zhou, Chunxiao, Bae-Jump, Victoria L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031332/ https://www.ncbi.nlm.nih.gov/pubmed/27655410 http://dx.doi.org/10.1186/s13045-016-0325-7

Ejemplares similares

Everolimus exhibits anti-tumorigenic activity in obesity-induced ovarian cancer
por: Guo, Hui, et al.
Publicado: (2016)

The Effects of NT-1044, a Novel AMPK Activator, on Endometrial Cancer Cell Proliferation, Apoptosis, Cell Stress and In Vivo Tumor Growth
por: Roque, Dario R., et al.
Publicado: (2021)

Phenformin has anti-tumorigenic effects in human ovarian cancer cells and in an orthotopic mouse model of serous ovarian cancer
por: Jackson, Amanda L., et al.
Publicado: (2017)

The HMG-CoA reductase inhibitor, simvastatin, exhibits anti-metastatic and anti-tumorigenic effects in ovarian cancer
por: Stine, Jessica E., et al.
Publicado: (2015)

JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer*
por: Qiu, Haifeng, et al.
Publicado: (2015)

The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer
por: Suri, Anuj, et al.
Publicado: (2016)

Dual inhibition of glycolysis and glutaminolysis as a therapeutic strategy in the treatment of ovarian cancer
por: Sun, Li, et al.
Publicado: (2017)

JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer
por: Qiu, Haifeng, et al.
Publicado: (2016)

Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
por: Han, Xiaoyun, et al.
Publicado: (2015)

Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide)
por: Sukakul, Thanisorn, et al.
Publicado: (2020)

Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway
por: Yuan, Lingqin, et al.
Publicado: (2015)

Asparagus officinalis Exhibits Anti-Tumorigenic and Anti-Metastatic Effects in Ovarian Cancer
por: Xu, Guangxu, et al.
Publicado: (2021)

Effects of biguanides on oxidative phosphorylation
por: Hirst, Judy
Publicado: (2014)

Synthetic accesses to biguanide compounds
por: Grytsai, Oleksandr, et al.
Publicado: (2021)

MacOS support essentials 10.14
por: Dreyer, Arek, et al.
Publicado: (2019)

SPR965, a Dual PI3K/mTOR Inhibitor, as a Targeted Therapy in Ovarian Cancer
por: Tran, Arthur-Quan, et al.
Publicado: (2021)

Evolution of the Pyrethroids Target-Site Resistance Mechanisms in Senegal: Early Stage of the Vgsc-1014F and Vgsc-1014S Allelic Frequencies Shift
por: Diallo, Moussa, et al.
Publicado: (2021)

Estrogen Induction of Telomerase Activity through Regulation of the Mitogen-Activated Protein Kinase (MAPK) Dependent Pathway in Human Endometrial Cancer Cells
por: Zhou, Chunxiao, et al.
Publicado: (2013)

Anti-Tumor and Anti-Invasive Effects of ONC201 on Ovarian Cancer Cells and a Transgenic Mouse Model of Serous Ovarian Cancer
por: Fan, Yali, et al.
Publicado: (2022)

Biguanides and targeted anti-cancer treatments
por: Hanly, Elyse K., et al.
Publicado: (2015)

Successful en bloc venous resection with reconstruction and subsequent radiotherapy for 2 consecutive recurrences of intravenous leiomyoma—a case report
por: Zhang, Ying, et al.
Publicado: (2016)

1014. Patient perspectives on pharmacy experiences for antiretroviral refills
por: Havens, Josh, et al.
Publicado: (2022)

Occurrence of L1014F and L1014S mutations in insecticide resistant Culex quinquefasciatus from filariasis endemic districts of West Bengal, India
por: Rai, Priyanka, et al.
Publicado: (2022)

Retraction: Occurrence of L1014F and L1014S mutations in insecticide resistant Culex quinquefasciatus from filariasis endemic districts of West Bengal, India
Publicado: (2023)

Lactobacillus acidophilus CRL 1014 improved “gut health” in the SHIME(®) reactor
por: Sivieri, Katia, et al.
Publicado: (2013)

1014. Microbiology and Outcome of Bloodstream Infections in Children With Intestinal Failure
por: Seddik, Talal, et al.
Publicado: (2018)

Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis
por: Ferrari, Giulio, et al.
Publicado: (2011)

Toxicological assessment of polyhexamethylene biguanide for water treatment
por: Asiedu-Gyekye, Isaac J., et al.
Publicado: (2015)

Three Cases of Lactic Acidosis Caused by Biguanides
por: Kuwahara, Masaatsu, et al.
Publicado: (2022)

Co-occurrence and distribution of East (L1014S) and West (L1014F) African knock-down resistance in Anopheles gambiae sensu lato population of Tanzania
por: Kabula, Bilali, et al.
Publicado: (2014)

Biguanides enhance antifungal activity against Candida glabrata
por: Xu, Shuying, et al.
Publicado: (2018)

Biguanides in combination with olaparib limits tumorigenesis of drug‐resistant ovarian cancer cells through inhibition of Snail
por: Wang, Qiong, et al.
Publicado: (2019)

Increased efficacy of metformin corresponds to differential metabolic effects in the ovarian tumors from obese versus lean mice
por: Han, Jianjun, et al.
Publicado: (2017)

Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells
por: Wang, Jiandong, et al.
Publicado: (2014)

Inhibition of CDK1 by RO-3306 Exhibits Anti-Tumorigenic Effects in Ovarian Cancer Cells and a Transgenic Mouse Model of Ovarian Cancer
por: Huang, Yu, et al.
Publicado: (2023)

Poster 1014: Omalizumab efficiency in patients with allergic rhinitis and chronic sinusitis
por: Gonzalez-Diaz, Sandra Nora, et al.
Publicado: (2014)

Synthesis and characterization of semiaromatic copolyamide 10T/1014 with high performance and flexibility
por: Feng, Wutong, et al.
Publicado: (2018)

Energy balance at the organism and cellular level: effects of biguanides
por: Pollak, Michael
Publicado: (2014)

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
por: Bridges, Hannah R., et al.
Publicado: (2014)

In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin
por: Laustriat, Delphine, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_iltuqao5ddg50ne3icdkq5g1c3