Characterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570

BACKGROUND: Aurantimycin (ATM), produced by Streptomyces aurantiacus JA 4570, is a potent antimicrobial and antitumor antibiotic. Although the chemical structure of ATM is highly distinctive and features a cyclohexadepsipeptide scaffold attached with a C(14) acyl side chain, little is known about it...

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Detalles Bibliográficos
Autores principales: Zhao, Houyuan, Wang, Liang, Wan, Dan, Qi, Jianzhao, Gong, Rong, Deng, Zixin, Chen, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031334/
https://www.ncbi.nlm.nih.gov/pubmed/27655321
http://dx.doi.org/10.1186/s12934-016-0559-7

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