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Heavy Alcohol Consumption with Alcoholic Liver Disease Accelerates Sarcopenia in Elderly Korean Males: The Korean National Health and Nutrition Examination Survey 2008-2010

BACKGROUND AND AIM: Although a few studies have reported that sarcopenia is associated with alcoholic liver disease (ALD), no studies have investigated this association in a large sample representative of the elderly Korean population. METHODS: This was a cross-sectional study that used data from th...

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Autores principales: Song, Do Seon, Chang, U Im, Choi, Sooa, Jung, Yun Duk, Han, Kyungdo, Ko, Seung-Hyun, Ahn, Yu-Bae, Yang, Jin Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031399/
https://www.ncbi.nlm.nih.gov/pubmed/27655344
http://dx.doi.org/10.1371/journal.pone.0163222
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author Song, Do Seon
Chang, U Im
Choi, Sooa
Jung, Yun Duk
Han, Kyungdo
Ko, Seung-Hyun
Ahn, Yu-Bae
Yang, Jin Mo
author_facet Song, Do Seon
Chang, U Im
Choi, Sooa
Jung, Yun Duk
Han, Kyungdo
Ko, Seung-Hyun
Ahn, Yu-Bae
Yang, Jin Mo
author_sort Song, Do Seon
collection PubMed
description BACKGROUND AND AIM: Although a few studies have reported that sarcopenia is associated with alcoholic liver disease (ALD), no studies have investigated this association in a large sample representative of the elderly Korean population. METHODS: This was a cross-sectional study that used data from the Fourth and Fifth Korean National Health and Nutrition Examination Surveys (KNHANES) on subjects aged 65 years and older. Sarcopenia was defined as a skeletal muscle index (SMI) more than 1 SD below the gender-specific mean for young adults; SMI was calculated as the appendicular muscle mass divided by height squared (ASM/Ht(2)). Heavy alcohol consumption was defined as consuming at least 210 g/week, and elevated liver enzymes were defined as alanine aminotransferase levels of at least 32 U/L or aspartate aminotransferase levels of at least 34 U/L. ALD was defined as heavy alcohol consumption and elevated liver enzymes. RESULTS: The mean age of the 1,151 elderly males was 71.6 ± 0.2 years, and the prevalence of heavy alcohol consumption was 11.8% (136 subjects). SMI did not differ between the non-heavy and heavy alcohol consumer groups (7.1 ± 0.0 kg/m(2) vs. 7.3 ± 0.1 kg/m(2), respectively, P = 0.145). However, after stratifying by the presence of liver disease and heavy alcohol consumption and adjusting for other confounders in the multivariate logistic regression, SMI was significantly lower among heavy alcohol consumers with ALD (all P < 0.05). Additionally, two-way ANOVA showed a significant interaction between heavy alcohol consumption and liver disease (P = 0.011). CONCLUSION: Sarcopenia was accelerated in the elderly male ALD group, with a significant interaction between alcohol consumption and liver disease.
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spelling pubmed-50313992016-10-10 Heavy Alcohol Consumption with Alcoholic Liver Disease Accelerates Sarcopenia in Elderly Korean Males: The Korean National Health and Nutrition Examination Survey 2008-2010 Song, Do Seon Chang, U Im Choi, Sooa Jung, Yun Duk Han, Kyungdo Ko, Seung-Hyun Ahn, Yu-Bae Yang, Jin Mo PLoS One Research Article BACKGROUND AND AIM: Although a few studies have reported that sarcopenia is associated with alcoholic liver disease (ALD), no studies have investigated this association in a large sample representative of the elderly Korean population. METHODS: This was a cross-sectional study that used data from the Fourth and Fifth Korean National Health and Nutrition Examination Surveys (KNHANES) on subjects aged 65 years and older. Sarcopenia was defined as a skeletal muscle index (SMI) more than 1 SD below the gender-specific mean for young adults; SMI was calculated as the appendicular muscle mass divided by height squared (ASM/Ht(2)). Heavy alcohol consumption was defined as consuming at least 210 g/week, and elevated liver enzymes were defined as alanine aminotransferase levels of at least 32 U/L or aspartate aminotransferase levels of at least 34 U/L. ALD was defined as heavy alcohol consumption and elevated liver enzymes. RESULTS: The mean age of the 1,151 elderly males was 71.6 ± 0.2 years, and the prevalence of heavy alcohol consumption was 11.8% (136 subjects). SMI did not differ between the non-heavy and heavy alcohol consumer groups (7.1 ± 0.0 kg/m(2) vs. 7.3 ± 0.1 kg/m(2), respectively, P = 0.145). However, after stratifying by the presence of liver disease and heavy alcohol consumption and adjusting for other confounders in the multivariate logistic regression, SMI was significantly lower among heavy alcohol consumers with ALD (all P < 0.05). Additionally, two-way ANOVA showed a significant interaction between heavy alcohol consumption and liver disease (P = 0.011). CONCLUSION: Sarcopenia was accelerated in the elderly male ALD group, with a significant interaction between alcohol consumption and liver disease. Public Library of Science 2016-09-21 /pmc/articles/PMC5031399/ /pubmed/27655344 http://dx.doi.org/10.1371/journal.pone.0163222 Text en © 2016 Song et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Song, Do Seon
Chang, U Im
Choi, Sooa
Jung, Yun Duk
Han, Kyungdo
Ko, Seung-Hyun
Ahn, Yu-Bae
Yang, Jin Mo
Heavy Alcohol Consumption with Alcoholic Liver Disease Accelerates Sarcopenia in Elderly Korean Males: The Korean National Health and Nutrition Examination Survey 2008-2010
title Heavy Alcohol Consumption with Alcoholic Liver Disease Accelerates Sarcopenia in Elderly Korean Males: The Korean National Health and Nutrition Examination Survey 2008-2010
title_full Heavy Alcohol Consumption with Alcoholic Liver Disease Accelerates Sarcopenia in Elderly Korean Males: The Korean National Health and Nutrition Examination Survey 2008-2010
title_fullStr Heavy Alcohol Consumption with Alcoholic Liver Disease Accelerates Sarcopenia in Elderly Korean Males: The Korean National Health and Nutrition Examination Survey 2008-2010
title_full_unstemmed Heavy Alcohol Consumption with Alcoholic Liver Disease Accelerates Sarcopenia in Elderly Korean Males: The Korean National Health and Nutrition Examination Survey 2008-2010
title_short Heavy Alcohol Consumption with Alcoholic Liver Disease Accelerates Sarcopenia in Elderly Korean Males: The Korean National Health and Nutrition Examination Survey 2008-2010
title_sort heavy alcohol consumption with alcoholic liver disease accelerates sarcopenia in elderly korean males: the korean national health and nutrition examination survey 2008-2010
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031399/
https://www.ncbi.nlm.nih.gov/pubmed/27655344
http://dx.doi.org/10.1371/journal.pone.0163222
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