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The Biophysical Basis Underlying Gating Changes in the p.V1316A Mutant Na(v)1.7 Channel and the Molecular Pathogenesis of Inherited Erythromelalgia
The Na(v)1.7 channel critically contributes to the excitability of sensory neurons, and gain-of-function mutations of this channel have been shown to cause inherited erythromelalgia (IEM) with neuropathic pain. In this study, we report a case of a severe phenotype of IEM caused by p.V1316A mutation...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031448/ https://www.ncbi.nlm.nih.gov/pubmed/27653502 http://dx.doi.org/10.1371/journal.pbio.1002561 |