Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium

BACKGROUND: Exacerbations of asthma and COPD are triggered by rhinoviruses. Uncontrolled inflammatory pathways, pathogenic bacterial burden and impaired antiviral immunity are thought to be important factors in disease severity and duration. Macrolides including azithromycin are often used to treat...

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Detalles Bibliográficos
Autores principales: Porter, James D., Watson, Jennifer, Roberts, Lee R., Gill, Simren K., Groves, Helen, Dhariwal, Jaideep, Almond, Mark H., Wong, Ernie, Walton, Ross P., Jones, Lyn H., Tregoning, John, Kilty, Iain, Johnston, Sebastian L., Edwards, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031920/
https://www.ncbi.nlm.nih.gov/pubmed/27494903
http://dx.doi.org/10.1093/jac/dkw222

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