Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice

Sepsis is characterized by systemic inflammation, edema formation and hypo-perfusion leading to organ dysfunction and ultimately death. Activation of the transient receptor potential vanilloid type 4 (TRPV4) channel is associated with edema formation and circulatory collapse. Here, we show that TRPV...

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Detalles Bibliográficos
Autores principales: Dalsgaard, Thomas, Sonkusare, Swapnil K., Teuscher, Cory, Poynter, Matthew E., Nelson, Mark T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031985/
https://www.ncbi.nlm.nih.gov/pubmed/27653046
http://dx.doi.org/10.1038/srep33841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031985/
https://www.ncbi.nlm.nih.gov/pubmed/27653046
http://dx.doi.org/10.1038/srep33841

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