Identification of gefitinib off-targets using a structure-based systems biology approach; their validation with reverse docking and retrospective data mining

Gefitinib, an EGFR tyrosine kinase inhibitor, is used as FDA approved drug in breast cancer and non-small cell lung cancer treatment. However, this drug has certain side effects and complications for which the underlying molecular mechanisms are not well understood. By systems biology based in silic...

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Detalles Bibliográficos
Autores principales: Verma, Nidhi, Rai, Amit Kumar, Kaushik, Vibha, Brünnert, Daniela, Chahar, Kirti Raj, Pandey, Janmejay, Goyal, Pankaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032012/
https://www.ncbi.nlm.nih.gov/pubmed/27653775
http://dx.doi.org/10.1038/srep33949

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