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MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations

How mutations in the microtubule-associated protein tau (MAPT) gene cause frontotemporal dementia (FTD) remains poorly understood. We generated and characterized multiple induced pluripotent stem cell (iPSC) lines from patients with MAPT IVS10+16 and tau-A152T mutations and a control subject. In cor...

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Detalles Bibliográficos
Autores principales:	Biswas, Md Helal U., Almeida, Sandra, Lopez-Gonzalez, Rodrigo, Mao, Wenjie, Zhang, Zhijun, Karydas, Anna, Geschwind, Michael D., Biernat, Jacek, Mandelkow, Eva-Maria, Futai, Kensuke, Miller, Bruce L., Gao, Fen-Biao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032669/ https://www.ncbi.nlm.nih.gov/pubmed/27594586 http://dx.doi.org/10.1016/j.stemcr.2016.08.006

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