Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7

Isoketals (IsoKs) are highly reactive γ-ketoaldehyde products of lipid peroxidation that covalently adduct lysine side chains in proteins, impairing their function. Using C. elegans as a model organism, we sought to test the hypothesis that IsoKs contribute to molecular aging through adduction and i...

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Detalles Bibliográficos
Autores principales: Nguyen, Thuy T., Caito, Samuel W., Zackert, William E., West, James D., Zhu, Shijun, Aschner, Michael, Fessel, Joshua P., Roberts, L. Jackson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032694/
https://www.ncbi.nlm.nih.gov/pubmed/27514077
http://dx.doi.org/10.18632/aging.101011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032694/
https://www.ncbi.nlm.nih.gov/pubmed/27514077
http://dx.doi.org/10.18632/aging.101011

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