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Survey of Two New (Kai 1 and Kai 2) and Other Blood Groups in Dogs of North America

BACKGROUND: Based upon serology, >10 canine blood group systems have been reported. OBJECTIVE: We surveyed dogs for dog erythrocyte antigen (DEA) 1 and 2 new blood types (Kai 1 and Kai 2), and some samples also were screened for Dal and DEA 3, 4, and 7. METHODS: Blood samples provided by owners,...

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Autores principales: Euler, C.C., Lee, J.H., Kim, H.Y., Raj, K., Mizukami, K., Giger, U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032879/
https://www.ncbi.nlm.nih.gov/pubmed/27627791
http://dx.doi.org/10.1111/jvim.14572
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author Euler, C.C.
Lee, J.H.
Kim, H.Y.
Raj, K.
Mizukami, K.
Giger, U.
author_facet Euler, C.C.
Lee, J.H.
Kim, H.Y.
Raj, K.
Mizukami, K.
Giger, U.
author_sort Euler, C.C.
collection PubMed
description BACKGROUND: Based upon serology, >10 canine blood group systems have been reported. OBJECTIVE: We surveyed dogs for dog erythrocyte antigen (DEA) 1 and 2 new blood types (Kai 1 and Kai 2), and some samples also were screened for Dal and DEA 3, 4, and 7. METHODS: Blood samples provided by owners, breeders, animal blood banks, and clinical laboratories were typed for DEA 1 by an immunochromatographic strip technique with a monoclonal antibody and analysis of band intensity. Both new antigens, the Dal and other DEAs (except DEA 7 by tube method), were assessed by a gel column method with either monoclonal or polyclonal antibodies. The same gel column method was applied for alloantibody detection. RESULTS: Of 503 dogs typed, 59.6% were DEA 1+ with 4% weakly, 10% moderately, and 45.6% strongly DEA 1+. Regarding Kai 1 and Kai 2, 94% were Kai 1+/Kai 2‐, 5% were Kai 1‐/Kai 2‐ and 1% were Kai 1‐/Kai 2+, but none were Kai 1+/Kai 2+. There was no relationship between Kai 1/Kai 2 and other blood types tested. Plasma from DEA 1‐, Kai 1‐, Kai 2‐ dogs, or some combination of these contained no detectable alloantibodies against DEA 1 and Kai 1 or Kai, respectively. CONCLUSIONS AND CLINICAL IMPORTANCE: The new blood types, called Kai 1 and Kai 2, are unrelated to DEA 1, 3, 4, and 7 and Dal. Kai 1+/Kai 2‐ dogs were most commonly found in North America. The clinical relevance of Kai 1 and Kai 2 in canine transfusion medicine still needs to be elucidated.
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spelling pubmed-50328792016-09-30 Survey of Two New (Kai 1 and Kai 2) and Other Blood Groups in Dogs of North America Euler, C.C. Lee, J.H. Kim, H.Y. Raj, K. Mizukami, K. Giger, U. J Vet Intern Med SMALL ANIMAL BACKGROUND: Based upon serology, >10 canine blood group systems have been reported. OBJECTIVE: We surveyed dogs for dog erythrocyte antigen (DEA) 1 and 2 new blood types (Kai 1 and Kai 2), and some samples also were screened for Dal and DEA 3, 4, and 7. METHODS: Blood samples provided by owners, breeders, animal blood banks, and clinical laboratories were typed for DEA 1 by an immunochromatographic strip technique with a monoclonal antibody and analysis of band intensity. Both new antigens, the Dal and other DEAs (except DEA 7 by tube method), were assessed by a gel column method with either monoclonal or polyclonal antibodies. The same gel column method was applied for alloantibody detection. RESULTS: Of 503 dogs typed, 59.6% were DEA 1+ with 4% weakly, 10% moderately, and 45.6% strongly DEA 1+. Regarding Kai 1 and Kai 2, 94% were Kai 1+/Kai 2‐, 5% were Kai 1‐/Kai 2‐ and 1% were Kai 1‐/Kai 2+, but none were Kai 1+/Kai 2+. There was no relationship between Kai 1/Kai 2 and other blood types tested. Plasma from DEA 1‐, Kai 1‐, Kai 2‐ dogs, or some combination of these contained no detectable alloantibodies against DEA 1 and Kai 1 or Kai, respectively. CONCLUSIONS AND CLINICAL IMPORTANCE: The new blood types, called Kai 1 and Kai 2, are unrelated to DEA 1, 3, 4, and 7 and Dal. Kai 1+/Kai 2‐ dogs were most commonly found in North America. The clinical relevance of Kai 1 and Kai 2 in canine transfusion medicine still needs to be elucidated. John Wiley and Sons Inc. 2016-09-14 2016 /pmc/articles/PMC5032879/ /pubmed/27627791 http://dx.doi.org/10.1111/jvim.14572 Text en Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle SMALL ANIMAL
Euler, C.C.
Lee, J.H.
Kim, H.Y.
Raj, K.
Mizukami, K.
Giger, U.
Survey of Two New (Kai 1 and Kai 2) and Other Blood Groups in Dogs of North America
title Survey of Two New (Kai 1 and Kai 2) and Other Blood Groups in Dogs of North America
title_full Survey of Two New (Kai 1 and Kai 2) and Other Blood Groups in Dogs of North America
title_fullStr Survey of Two New (Kai 1 and Kai 2) and Other Blood Groups in Dogs of North America
title_full_unstemmed Survey of Two New (Kai 1 and Kai 2) and Other Blood Groups in Dogs of North America
title_short Survey of Two New (Kai 1 and Kai 2) and Other Blood Groups in Dogs of North America
title_sort survey of two new (kai 1 and kai 2) and other blood groups in dogs of north america
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032879/
https://www.ncbi.nlm.nih.gov/pubmed/27627791
http://dx.doi.org/10.1111/jvim.14572
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