Effects of Microglia on Neurogenesis

This review summarizes and organizes the literature concerning the effects of microglia on neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is progressively restricted durin...

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Detalles Bibliográficos
Autor principal: Sato, Kaoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Section 1: Stem and Progenitor Cells in Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032973/
https://www.ncbi.nlm.nih.gov/pubmed/26010551
http://dx.doi.org/10.1002/glia.22858
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author Sato, Kaoru
author_facet Sato, Kaoru
author_sort Sato, Kaoru
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description This review summarizes and organizes the literature concerning the effects of microglia on neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is progressively restricted during the life of the organism. A comparison of microglial roles in neurogenesis in these two regions indicates that microglia regulate neurogenesis in a temporally and spatially specific manner. Microglia may also sense signals from the surrounding environment and have regulatory effects on neurogenesis. We speculate microglia function as a hub for the information obtained from the inner and outer brain regions for regulating neurogenesis. GLIA 2015;63:1394–1405
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spelling pubmed-50329732016-10-03 Effects of Microglia on Neurogenesis Sato, Kaoru Glia Section 1: Stem and Progenitor Cells in Development This review summarizes and organizes the literature concerning the effects of microglia on neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is progressively restricted during the life of the organism. A comparison of microglial roles in neurogenesis in these two regions indicates that microglia regulate neurogenesis in a temporally and spatially specific manner. Microglia may also sense signals from the surrounding environment and have regulatory effects on neurogenesis. We speculate microglia function as a hub for the information obtained from the inner and outer brain regions for regulating neurogenesis. GLIA 2015;63:1394–1405 John Wiley and Sons Inc. 2015-05-24 2015-08 /pmc/articles/PMC5032973/ /pubmed/26010551 http://dx.doi.org/10.1002/glia.22858 Text en © 2015 The Authors. Glia Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Section 1: Stem and Progenitor Cells in Development
Sato, Kaoru
Effects of Microglia on Neurogenesis
title Effects of Microglia on Neurogenesis
title_full Effects of Microglia on Neurogenesis
title_fullStr Effects of Microglia on Neurogenesis
title_full_unstemmed Effects of Microglia on Neurogenesis
title_short Effects of Microglia on Neurogenesis
title_sort effects of microglia on neurogenesis
topic Section 1: Stem and Progenitor Cells in Development
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032973/
https://www.ncbi.nlm.nih.gov/pubmed/26010551
http://dx.doi.org/10.1002/glia.22858
work_keys_str_mv AT satokaoru effectsofmicrogliaonneurogenesis

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