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Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

Thymic epithelial cell differentiation, growth and function depend on the expression of the transcription factor Foxn1, however its target genes have never been physically identified. Using novel static and inducible genetic model systems and chromatin studies, we provide now a genome wide map of di...

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Detalles Bibliográficos
Autores principales: Žuklys, Saulius, Handel, Adam, Zhanybekova, Saule, Govani, Fatima, Keller, Marcel, Maio, Stefano, Mayer, Carlos E., Teh, Hong Ying, Hafen, Katrin, Gallone, Giuseppe, Barthlott, Thomas, Ponting, Chris P., Holländer, Georg A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033077/
https://www.ncbi.nlm.nih.gov/pubmed/27548434
http://dx.doi.org/10.1038/ni.3537