Cargando…
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells
Thymic epithelial cell differentiation, growth and function depend on the expression of the transcription factor Foxn1, however its target genes have never been physically identified. Using novel static and inducible genetic model systems and chromatin studies, we provide now a genome wide map of di...
Autores principales: | Žuklys, Saulius, Handel, Adam, Zhanybekova, Saule, Govani, Fatima, Keller, Marcel, Maio, Stefano, Mayer, Carlos E., Teh, Hong Ying, Hafen, Katrin, Gallone, Giuseppe, Barthlott, Thomas, Ponting, Chris P., Holländer, Georg A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033077/ https://www.ncbi.nlm.nih.gov/pubmed/27548434 http://dx.doi.org/10.1038/ni.3537 |
Ejemplares similares
-
Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development
por: Handel, Adam E., et al.
Publicado: (2018) -
Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
por: Barthlott, Thomas, et al.
Publicado: (2021) -
Dynamic spatio‐temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla
por: Mayer, Carlos E., et al.
Publicado: (2016) -
Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution
por: García-León, María Jesús, et al.
Publicado: (2022) -
Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia
por: Sansom, Stephen N., et al.
Publicado: (2014)