The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance

Panitumumab and cetuximab target the epidermal growth factor receptor for the treatment of metastatic colorectal cancer. These therapies provide a significant survival benefit to patients with metastatic colorectal cancer with wild-type RAS. A single point mutation in the ectodomain of EGFR (S468R)...

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Detalles Bibliográficos
Autores principales: Sickmier, E. Allen, Kurzeja, Robert J. M., Michelsen, Klaus, Vazir, Mukta, Yang, Evelyn, Tasker, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033319/
https://www.ncbi.nlm.nih.gov/pubmed/27658254
http://dx.doi.org/10.1371/journal.pone.0163366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033319/
https://www.ncbi.nlm.nih.gov/pubmed/27658254
http://dx.doi.org/10.1371/journal.pone.0163366

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