Cargando…

A Rationally Designed TNF-α Epitope-Scaffold Immunogen Induces Sustained Antibody Response and Alleviates Collagen-Induced Arthritis in Mice

The TNF-α biological inhibitors have significantly improved the clinical outcomes of many autoimmune diseases, in particular rheumatoid arthritis. However, the practical uses are limited due to high costs and the risk of anti-drug antibody responses. Attempts to develop anti-TNF-α vaccines have gene...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Li, Wang, Jin, Xu, Aizhang, Zhong, Conghao, Lu, Wuguang, Deng, Li, Li, Rongxiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033357/ https://www.ncbi.nlm.nih.gov/pubmed/27658047 http://dx.doi.org/10.1371/journal.pone.0163080

Ejemplares similares

The Protective Antibodies Induced by a Novel Epitope of Human TNF-α Could Suppress the Development of Collagen-Induced Arthritis
por: Dong, Jie, et al.
Publicado: (2010)

Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model
por: Wang, Tengteng, et al.
Publicado: (2020)

TNF-α Induces Mitophagy in Rheumatoid Arthritis Synovial Fibroblasts, and Mitophagy Inhibition Alleviates Synovitis in Collagen Antibody-Induced Arthritis
por: Nam, Ji-Hee, et al.
Publicado: (2022)

Corrigendum: Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model
por: Wang, Tengteng, et al.
Publicado: (2020)

Trivalent soluble TNF Receptor, a potent TNF-α antagonist for the treatment collagen-induced arthritis
por: Cui, Xiaofang, et al.
Publicado: (2018)

Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis
por: Andersson, Sofia E. M., et al.
Publicado: (2016)

Taxol alleviates collagen-induced arthritis in mice by inhibiting the formation of microvessels
por: Xu, Juan, et al.
Publicado: (2017)

Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis
por: Wang, Qingtong, et al.
Publicado: (2017)

Identification of an immunosuppressive epitope of type II collagen that confers protection against collagen-induced arthritis
Publicado: (1989)

TNF-alpha blockade by nonviral gene therapy in collagen-induced arthritis
por: Boissier, MC, et al.
Publicado: (2003)

Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells
por: Cao, Gan, et al.
Publicado: (2023)

Imperatorin and β‐sitosterol have synergistic activities in alleviating collagen‐induced arthritis
por: Guo, Qingqing, et al.
Publicado: (2020)

The Immunogenicity and Anti-tumor Efficacy of a Rationally Designed Neoantigen Vaccine for B16F10 Mouse Melanoma
por: Zhang, Yan, et al.
Publicado: (2019)

Abdominal vagus nerve stimulation alleviates collagen-induced arthritis in rats
por: Payne, Sophie C., et al.
Publicado: (2022)

Inhibition of GSK-3β Alleviates Collagen II-Induced Rheumatoid Arthritis in Rats
por: Zhou, Haiyan, et al.
Publicado: (2016)

Salubrinal Alleviates Collagen-Induced Arthritis through Promoting P65 Degradation in Osteoclastogenesis
por: Wang, Ziyu, et al.
Publicado: (2021)

Blocking Interleukin-33 Alleviates the Joint Inflammation and Inhibits the Development of Collagen-Induced Arthritis in Mice
por: Li, Yan, et al.
Publicado: (2020)

Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice
por: Bian, Li, et al.
Publicado: (2009)

Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen
por: Bajtner, Estelle, et al.
Publicado: (2005)

Alleviation of Collagen-Induced Arthritis by Crotonoside through Modulation of Dendritic Cell Differentiation and Activation
por: Lin, Shih-Chao, et al.
Publicado: (2020)

Suppression of Dendritic Cell Maturation by Kefir Peptides Alleviates Collagen-Induced Arthritis in Mice
por: Chen, Chien-Fu, et al.
Publicado: (2021)

IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia
por: Xu, Aizhang, et al.
Publicado: (2016)

Rationally designed ligand‐independent peptide inhibitors of TREM‐1 ameliorate collagen‐induced arthritis
por: Shen, Zu T., et al.
Publicado: (2017)

Pien Tze Huang alleviate the joint inflammation in collagen-induced arthritis mice
por: Deng, YongQi, et al.
Publicado: (2020)

Sustained microglial activation in the area postrema of collagen-induced arthritis mice
por: Matsushita, Takayuki, et al.
Publicado: (2021)

TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models
por: Wu, Jiao, et al.
Publicado: (2022)

Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II-induced arthritis
por: Li, Zhe-Yong, et al.
Publicado: (2019)

The effect of TNF-α inhibitor treatment on microRNAs and endothelial function in collagen induced arthritis
por: Gunter, Sulè, et al.
Publicado: (2022)

Hepatorenal pathologies in TNF-transgenic mouse model of rheumatoid arthritis are alleviated by anti-TNF treatment
por: Li, Xuefei, et al.
Publicado: (2023)

Isoegomaketone Alleviates the Development of Collagen Antibody-Induced Arthritis in Male Balb/c Mice
por: Jin, Chang Hyun, et al.
Publicado: (2017)

Erianin alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation
por: Tsai, Sen-Wei, et al.
Publicado: (2023)

Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate
por: Zuo, Jian, et al.
Publicado: (2018)

Shexiang-Wulong Pills Attenuate Rheumatoid Arthritis by Alleviating Inflammation in a Mouse Model of Collagen-Induced Arthritis
por: Zhang, Zhihui, et al.
Publicado: (2019)

Carnosol Alleviates Collagen-Induced Arthritis by Inhibiting Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells
por: Chen, Jun, et al.
Publicado: (2023)

Downregulation of Hypoxia-Inducible Factor-1α by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats
por: Hu, Yiping, et al.
Publicado: (2020)

Transcriptomics‐based analysis of the mechanism by which Wang-Bi capsule alleviates joint destruction in rats with collagen‐induced arthritis
por: Shu, Haiyang, et al.
Publicado: (2021)

Dopamine D2 Receptor Is Involved in Alleviation of Type II Collagen-Induced Arthritis in Mice
por: Lu, Jian-Hua, et al.
Publicado: (2015)

CysLT1 receptor antagonist alleviates pathogenesis of collagen-induced arthritis mouse model
por: Xu, Minwen, et al.
Publicado: (2017)

Wang-Bi Capsule Alleviates the Joint Inflammation and Bone Destruction in Mice with Collagen-Induced Arthritis
por: Cui, Hua, et al.
Publicado: (2020)

Angiotensin AT(2) Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers
por: Sehnert, Bettina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2j4jo71pscoqco3ot1lh66rksm