MiRNA-Embedded ShRNAs for Radiation-Inducible LGMN Knockdown and the Antitumor Effects on Breast Cancer

Legumain (LGMN) is highly expressed in breast cancer (BC) and other solid tumors and is a potential anticancer target. Here we investigate the anti-tumor effects of short hairpin RNAs (shRNAs) targeting LGMN embedded in a microRNA-155 (miR-155) architecture, which is driven by a radiation-inducible...

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Detalles Bibliográficos
Autores principales: Zhang, Zhi-Qiang, Cao, Zhi, Liu, Cong, Li, Rong, Wang, Wei-Dong, Wang, Xing-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033420/
https://www.ncbi.nlm.nih.gov/pubmed/27656894
http://dx.doi.org/10.1371/journal.pone.0163446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033420/
https://www.ncbi.nlm.nih.gov/pubmed/27656894
http://dx.doi.org/10.1371/journal.pone.0163446

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