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Insulin-Like Growth Factor I (IGF-I) Expressed from an AAV1 Vector Leads to a Complete Reversion of Liver Cirrhosis in Rats

IGF-I modulates liver tissue homeostasis. It is produced by hepatocytes and signals within the liver through IGF-I receptor expressed on hepatic stellate cells (HSCs). Liver cirrhosis is characterized by marked IGF-I deficiency. Here we compared the effect of two different gene therapy vectors encod...

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Detalles Bibliográficos
Autores principales:	Sobrevals, Luciano, Enguita, Mónica, Quiroga, Jorge, Prieto, Jesús, Fortes, Puri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033470/ https://www.ncbi.nlm.nih.gov/pubmed/27658043 http://dx.doi.org/10.1371/journal.pone.0162955

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