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Noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography
BACKGROUND AND OBJECTIVES: A method of identifying retinal vascular microaneurysms (MAs) in nonproliferative diabetic retinopathy (NPDR) using swept-source optical coherence tomography (SS-OCT). PATIENTS AND METHODS: SS-OCT images were acquired in 17 eyes with NPDR using prototype SS-OCT device and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033498/ https://www.ncbi.nlm.nih.gov/pubmed/27695284 http://dx.doi.org/10.2147/OPTH.S115016 |
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author | Cheng, Sarah Leng, Theodore |
author_facet | Cheng, Sarah Leng, Theodore |
author_sort | Cheng, Sarah |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: A method of identifying retinal vascular microaneurysms (MAs) in nonproliferative diabetic retinopathy (NPDR) using swept-source optical coherence tomography (SS-OCT). PATIENTS AND METHODS: SS-OCT images were acquired in 17 eyes with NPDR using prototype SS-OCT device and fluorescein angiography (FA) images were obtained simultaneously. MAs identified on SS-OCT slabs were correlated to MAs identified on FA. RESULTS: MAs were identified in SS-OCT slabs in 15/17 eyes, resulting in NPDR diagnosis rate of 88%. Mean number of MAs identified on FA was 11.7±11.9 (total 199) and was 8.1±9.3 (total 137) on SS-OCT. Wilcoxon rank sum test showed no significant difference in MAs detected on SS-OCT and FA (P=0.2995) across eyes. Wilcoxon rank sum test showed SS-OCT detected slightly fewer MAs than FA per eye (3.65 less, P=0.0009). CONCLUSION: SS-OCT visualization of MAs could serve as a tool for diagnosing NPDR, and possibly applied as an imaging biomarker for population-based diabetic retinopathy screening. |
format | Online Article Text |
id | pubmed-5033498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-50334982016-09-30 Noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography Cheng, Sarah Leng, Theodore Clin Ophthalmol Original Research BACKGROUND AND OBJECTIVES: A method of identifying retinal vascular microaneurysms (MAs) in nonproliferative diabetic retinopathy (NPDR) using swept-source optical coherence tomography (SS-OCT). PATIENTS AND METHODS: SS-OCT images were acquired in 17 eyes with NPDR using prototype SS-OCT device and fluorescein angiography (FA) images were obtained simultaneously. MAs identified on SS-OCT slabs were correlated to MAs identified on FA. RESULTS: MAs were identified in SS-OCT slabs in 15/17 eyes, resulting in NPDR diagnosis rate of 88%. Mean number of MAs identified on FA was 11.7±11.9 (total 199) and was 8.1±9.3 (total 137) on SS-OCT. Wilcoxon rank sum test showed no significant difference in MAs detected on SS-OCT and FA (P=0.2995) across eyes. Wilcoxon rank sum test showed SS-OCT detected slightly fewer MAs than FA per eye (3.65 less, P=0.0009). CONCLUSION: SS-OCT visualization of MAs could serve as a tool for diagnosing NPDR, and possibly applied as an imaging biomarker for population-based diabetic retinopathy screening. Dove Medical Press 2016-09-16 /pmc/articles/PMC5033498/ /pubmed/27695284 http://dx.doi.org/10.2147/OPTH.S115016 Text en © 2016 Cheng and Leng. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Cheng, Sarah Leng, Theodore Noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography |
title | Noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography |
title_full | Noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography |
title_fullStr | Noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography |
title_full_unstemmed | Noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography |
title_short | Noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography |
title_sort | noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033498/ https://www.ncbi.nlm.nih.gov/pubmed/27695284 http://dx.doi.org/10.2147/OPTH.S115016 |
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