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A Novel Inhibitor of 5-Lipoxygenase (5-LOX) Prevents Oxidative Stress–Induced Cell Death of Retinal Pigment Epithelium (RPE) Cells

PURPOSE: 5-Lipoxygenase (5-LOX) oxygenates arachidonic acid to form 5-hydroperoxyeicosatetraenoic acid, which is further converted into biologically detrimental leukotrienes, such as leukotriene B4 (LTB(4)). The RPE and retina express the PNPLA2 gene for pigment epithelium–derived factor receptor (P...

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Detalles Bibliográficos
Autores principales:	Subramanian, Preeti, Mendez, Emily F., Becerra, S. Patricia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033602/ https://www.ncbi.nlm.nih.gov/pubmed/27635633 http://dx.doi.org/10.1167/iovs.15-19039

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