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Management of malignant pleural mesothelioma – part 1: epidemiology, diagnosis, and staging: Consensus of the Austrian Mesothelioma Interest Group (AMIG)

Malignant pleural mesothelioma is a rare malignant disease that in the majority of cases is associated with asbestos exposure. The incidence in Europe is about 20 per million inhabitants and it is increasing worldwide. Initial symptoms are shortness of breath, pleural effusion, cough, and chest pain...

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Autores principales: Geltner, Christian, Errhalt, Peter, Baumgartner, Bernhard, Ambrosch, Gerhard, Machan, Barbara, Eckmayr, Josef, Klikovits, Thomas, Hoda, Mir Alireza, Popper, Helmut, Klepetko, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033998/
https://www.ncbi.nlm.nih.gov/pubmed/27619223
http://dx.doi.org/10.1007/s00508-016-1080-z
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author Geltner, Christian
Errhalt, Peter
Baumgartner, Bernhard
Ambrosch, Gerhard
Machan, Barbara
Eckmayr, Josef
Klikovits, Thomas
Hoda, Mir Alireza
Popper, Helmut
Klepetko, Walter
author_facet Geltner, Christian
Errhalt, Peter
Baumgartner, Bernhard
Ambrosch, Gerhard
Machan, Barbara
Eckmayr, Josef
Klikovits, Thomas
Hoda, Mir Alireza
Popper, Helmut
Klepetko, Walter
author_sort Geltner, Christian
collection PubMed
description Malignant pleural mesothelioma is a rare malignant disease that in the majority of cases is associated with asbestos exposure. The incidence in Europe is about 20 per million inhabitants and it is increasing worldwide. Initial symptoms are shortness of breath, pleural effusion, cough, and chest pain. The typical growth pattern is along the pleural surface; however, infiltration of the lung and/or mediastinal and chest wall structures can occur in a more advanced stage. Ultimately, distant metastases outside the chest can result. Several histological subtypes of pleural mesothelioma exist, which must be differentiated from either benign diseases or metastases in the pleural space by other tumor entities. This differential diagnosis can be very difficult and a large panel of immunohistochemical markers is required to establish the exact diagnosis. The standard procedure for confirming the disease and obtaining sufficient tissue for the diagnosis is videothoracoscopy. Full thickness biopsies are required, while transthoracic needle puncture of pleural fluid or tissue is considered to be insufficient for a cytological diagnosis. Complete and detailed staging is mandatory for categorization of the disease as well as for therapeutic decision making.
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spelling pubmed-50339982016-10-09 Management of malignant pleural mesothelioma – part 1: epidemiology, diagnosis, and staging: Consensus of the Austrian Mesothelioma Interest Group (AMIG) Geltner, Christian Errhalt, Peter Baumgartner, Bernhard Ambrosch, Gerhard Machan, Barbara Eckmayr, Josef Klikovits, Thomas Hoda, Mir Alireza Popper, Helmut Klepetko, Walter Wien Klin Wochenschr Consensus Report Malignant pleural mesothelioma is a rare malignant disease that in the majority of cases is associated with asbestos exposure. The incidence in Europe is about 20 per million inhabitants and it is increasing worldwide. Initial symptoms are shortness of breath, pleural effusion, cough, and chest pain. The typical growth pattern is along the pleural surface; however, infiltration of the lung and/or mediastinal and chest wall structures can occur in a more advanced stage. Ultimately, distant metastases outside the chest can result. Several histological subtypes of pleural mesothelioma exist, which must be differentiated from either benign diseases or metastases in the pleural space by other tumor entities. This differential diagnosis can be very difficult and a large panel of immunohistochemical markers is required to establish the exact diagnosis. The standard procedure for confirming the disease and obtaining sufficient tissue for the diagnosis is videothoracoscopy. Full thickness biopsies are required, while transthoracic needle puncture of pleural fluid or tissue is considered to be insufficient for a cytological diagnosis. Complete and detailed staging is mandatory for categorization of the disease as well as for therapeutic decision making. Springer Vienna 2016-09-12 2016 /pmc/articles/PMC5033998/ /pubmed/27619223 http://dx.doi.org/10.1007/s00508-016-1080-z Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Consensus Report
Geltner, Christian
Errhalt, Peter
Baumgartner, Bernhard
Ambrosch, Gerhard
Machan, Barbara
Eckmayr, Josef
Klikovits, Thomas
Hoda, Mir Alireza
Popper, Helmut
Klepetko, Walter
Management of malignant pleural mesothelioma – part 1: epidemiology, diagnosis, and staging: Consensus of the Austrian Mesothelioma Interest Group (AMIG)
title Management of malignant pleural mesothelioma – part 1: epidemiology, diagnosis, and staging: Consensus of the Austrian Mesothelioma Interest Group (AMIG)
title_full Management of malignant pleural mesothelioma – part 1: epidemiology, diagnosis, and staging: Consensus of the Austrian Mesothelioma Interest Group (AMIG)
title_fullStr Management of malignant pleural mesothelioma – part 1: epidemiology, diagnosis, and staging: Consensus of the Austrian Mesothelioma Interest Group (AMIG)
title_full_unstemmed Management of malignant pleural mesothelioma – part 1: epidemiology, diagnosis, and staging: Consensus of the Austrian Mesothelioma Interest Group (AMIG)
title_short Management of malignant pleural mesothelioma – part 1: epidemiology, diagnosis, and staging: Consensus of the Austrian Mesothelioma Interest Group (AMIG)
title_sort management of malignant pleural mesothelioma – part 1: epidemiology, diagnosis, and staging: consensus of the austrian mesothelioma interest group (amig)
topic Consensus Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033998/
https://www.ncbi.nlm.nih.gov/pubmed/27619223
http://dx.doi.org/10.1007/s00508-016-1080-z
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