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A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABA(A)), Receptor Subunit Binding Selectivity in Synaptosomes
Propofol, an intravenous anesthetic, is a positive modulator of the GABA(A) receptor, but the mechanistic details, including the relevant binding sites and alternative targets, remain disputed. Here we undertook an in-depth study of alkylphenol-based anesthetic binding to synaptic membranes. We desi...
Autores principales: | Woll, Kellie A., Murlidaran, Sruthi, Pinch, Benika J., Hénin, Jérôme, Wang, Xiaoshi, Salari, Reza, Covarrubias, Manuel, Dailey, William P., Brannigan, Grace, Garcia, Benjamin A., Eckenhoff, Roderic G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034043/ https://www.ncbi.nlm.nih.gov/pubmed/27462076 http://dx.doi.org/10.1074/jbc.M116.736975 |
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