FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF

Patients with Parkinson's disease (PD) often have aggregated α-synuclein (aSyn) in enteric nervous system (ENS) neurons, which may be associated with the development of constipation. This occurs well before the onset of classic PD motor symptoms. We previously found that aging A53T transgenic (...

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Detalles Bibliográficos
Autores principales: Vidal-Martínez, Guadalupe, Vargas-Medrano, Javier, Gil-Tommee, Carolina, Medina, David, Garza, Nathan T., Yang, Barbara, Segura-Ulate, Ismael, Dominguez, Samantha J., Perez, Ruth G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034069/
https://www.ncbi.nlm.nih.gov/pubmed/27528608
http://dx.doi.org/10.1074/jbc.M116.744029

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