TALEN-based generation of a cynomolgus monkey disease model for human microcephaly

Gene editing in non-human primates may lead to valuable models for exploring the etiologies and therapeutic strategies of genetically based neurological disorders in humans. However, a monkey model of neurological disorders that closely mimics pathological and behavioral deficits in humans has not y...

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Detalles Bibliográficos
Autores principales: Ke, Qiong, Li, Weiqiang, Lai, Xingqiang, Chen, Hong, Huang, Lihua, Kang, Zhuang, Li, Kai, Ren, Jie, Lin, Xiaofeng, Zheng, Haiqing, Huang, Weijun, Ma, Yunhan, Xu, Dongdong, Chen, Zheng, Song, Xinming, Lin, Xinyi, Zhuang, Min, Wang, Tao, Zhuang, Fengfeng, Xi, Jianzhong, Mao, Frank Fuxiang, Xia, Huimin, Lahn, Bruce T, Zhou, Qi, Yang, Shihua, Xiang, Andy Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034111/
https://www.ncbi.nlm.nih.gov/pubmed/27502025
http://dx.doi.org/10.1038/cr.2016.93

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