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Helical unwinding and side-chain unlocking unravel the outward open conformation of the melibiose transporter
Molecular dynamics simulations have been used to study the alternate access mechanism of the melibiose transporter from Escherichia coli. Starting from the outward-facing partially occluded form, 2 out of 12 simulations produced an outward full open form and one partially open, whereas the rest yiel...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034317/ https://www.ncbi.nlm.nih.gov/pubmed/27658476 http://dx.doi.org/10.1038/srep33776 |