Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL...

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Detalles Bibliográficos
Autores principales: Jiang, Zhiwu, Deng, Manman, Wei, Xinru, Ye, Wei, Xiao, Yiren, Lin, Simiao, Wang, Suna, Li, Baiheng, Liu, Xin, Zhang, Gong, Lai, Peilong, Weng, Jianyu, Wu, Donghai, Chen, Haijia, Wei, Wei, Ma, Yuguo, Li, Yangqiu, Liu, Pentao, Du, Xin, Pei, Duanqing, Yao, Yao, Xu, Bing, Li, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034590/
https://www.ncbi.nlm.nih.gov/pubmed/27660152
http://dx.doi.org/10.1186/s13045-016-0310-1
Descripción
Sumario:The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-016-0310-1) contains supplementary material, which is available to authorized users.

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