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Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized
The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034590/ https://www.ncbi.nlm.nih.gov/pubmed/27660152 http://dx.doi.org/10.1186/s13045-016-0310-1 |
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| author | Jiang, Zhiwu Deng, Manman Wei, Xinru Ye, Wei Xiao, Yiren Lin, Simiao Wang, Suna Li, Baiheng Liu, Xin Zhang, Gong Lai, Peilong Weng, Jianyu Wu, Donghai Chen, Haijia Wei, Wei Ma, Yuguo Li, Yangqiu Liu, Pentao Du, Xin Pei, Duanqing Yao, Yao Xu, Bing Li, Peng |
| author_facet | Jiang, Zhiwu Deng, Manman Wei, Xinru Ye, Wei Xiao, Yiren Lin, Simiao Wang, Suna Li, Baiheng Liu, Xin Zhang, Gong Lai, Peilong Weng, Jianyu Wu, Donghai Chen, Haijia Wei, Wei Ma, Yuguo Li, Yangqiu Liu, Pentao Du, Xin Pei, Duanqing Yao, Yao Xu, Bing Li, Peng |
| author_sort | Jiang, Zhiwu |
| collection | PubMed |
| description | The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-016-0310-1) contains supplementary material, which is available to authorized users. |
| format | Online Article Text |
| id | pubmed-5034590 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-50345902016-09-29 Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized Jiang, Zhiwu Deng, Manman Wei, Xinru Ye, Wei Xiao, Yiren Lin, Simiao Wang, Suna Li, Baiheng Liu, Xin Zhang, Gong Lai, Peilong Weng, Jianyu Wu, Donghai Chen, Haijia Wei, Wei Ma, Yuguo Li, Yangqiu Liu, Pentao Du, Xin Pei, Duanqing Yao, Yao Xu, Bing Li, Peng J Hematol Oncol Letter to the Editor The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-016-0310-1) contains supplementary material, which is available to authorized users. BioMed Central 2016-09-22 /pmc/articles/PMC5034590/ /pubmed/27660152 http://dx.doi.org/10.1186/s13045-016-0310-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Letter to the Editor Jiang, Zhiwu Deng, Manman Wei, Xinru Ye, Wei Xiao, Yiren Lin, Simiao Wang, Suna Li, Baiheng Liu, Xin Zhang, Gong Lai, Peilong Weng, Jianyu Wu, Donghai Chen, Haijia Wei, Wei Ma, Yuguo Li, Yangqiu Liu, Pentao Du, Xin Pei, Duanqing Yao, Yao Xu, Bing Li, Peng Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized |
| title | Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized |
| title_full | Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized |
| title_fullStr | Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized |
| title_full_unstemmed | Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized |
| title_short | Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized |
| title_sort | heterogeneity of cd34 and cd38 expression in acute b lymphoblastic leukemia cells is reversible and not hierarchically organized |
| topic | Letter to the Editor |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034590/ https://www.ncbi.nlm.nih.gov/pubmed/27660152 http://dx.doi.org/10.1186/s13045-016-0310-1 |
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