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Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP‐dependent manner

The interaction of Regulator of G protein Signaling 4 (RGS4) with the rat mu opioid receptor (MOR)/G protein complex was investigated. Solubilized MOR from rat brain membranes was immunoprecipitated in the presence of RGS4 with antibodies against the N‐terminus of MOR (anti‐MOR(10–70)). Activation o...

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Detalles Bibliográficos
Autores principales: Santhappan, Rema, Crowder, Alicia Tamara, Gouty, Shawn, Cox, Brian M., Côté, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034817/
https://www.ncbi.nlm.nih.gov/pubmed/26119705
http://dx.doi.org/10.1111/jnc.13222