Virus‐Surface‐Mimicking Surface Clustering of AuNPs onto DNA‐Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster‐Induced NIR Photothermal Therapy

Virus‐surface‐mimicking decoration of deoxyribonucleic acid (DNA)‐entrapped polymeric nanoparticle with AuNPs is demonstrated to lead to enhanced cellular uptake, improved gene transfection, and particularly efficient near‐infrared photothermal therapy that cannot be achieved by both of them separat...

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Detalles Bibliográficos
Autores principales: Jia, Hui‐Zhen, Chen, Wei‐Hai, Wang, Xuli, Lei, Qi, Yin, Wei‐Na, Wang, Yan, Zhuo, Ren‐Xi, Feng, Jun, Zhang, Xian‐Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034825/
https://www.ncbi.nlm.nih.gov/pubmed/27708995
http://dx.doi.org/10.1002/advs.201500108
Descripción
Sumario:Virus‐surface‐mimicking decoration of deoxyribonucleic acid (DNA)‐entrapped polymeric nanoparticle with AuNPs is demonstrated to lead to enhanced cellular uptake, improved gene transfection, and particularly efficient near‐infrared photothermal therapy that cannot be achieved by both of them separately. This hybrid nanosystem represents a novel paradigm of multipurpose organic–inorganic nanoplatform, especially for cancer treatments. [Image: see text]

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