Virus‐Surface‐Mimicking Surface Clustering of AuNPs onto DNA‐Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster‐Induced NIR Photothermal Therapy

Virus‐surface‐mimicking decoration of deoxyribonucleic acid (DNA)‐entrapped polymeric nanoparticle with AuNPs is demonstrated to lead to enhanced cellular uptake, improved gene transfection, and particularly efficient near‐infrared photothermal therapy that cannot be achieved by both of them separat...

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Detalles Bibliográficos
Autores principales: Jia, Hui‐Zhen, Chen, Wei‐Hai, Wang, Xuli, Lei, Qi, Yin, Wei‐Na, Wang, Yan, Zhuo, Ren‐Xi, Feng, Jun, Zhang, Xian‐Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034825/
https://www.ncbi.nlm.nih.gov/pubmed/27708995
http://dx.doi.org/10.1002/advs.201500108
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author Jia, Hui‐Zhen
Chen, Wei‐Hai
Wang, Xuli
Lei, Qi
Yin, Wei‐Na
Wang, Yan
Zhuo, Ren‐Xi
Feng, Jun
Zhang, Xian‐Zheng
author_facet Jia, Hui‐Zhen
Chen, Wei‐Hai
Wang, Xuli
Lei, Qi
Yin, Wei‐Na
Wang, Yan
Zhuo, Ren‐Xi
Feng, Jun
Zhang, Xian‐Zheng
author_sort Jia, Hui‐Zhen
collection PubMed
description Virus‐surface‐mimicking decoration of deoxyribonucleic acid (DNA)‐entrapped polymeric nanoparticle with AuNPs is demonstrated to lead to enhanced cellular uptake, improved gene transfection, and particularly efficient near‐infrared photothermal therapy that cannot be achieved by both of them separately. This hybrid nanosystem represents a novel paradigm of multipurpose organic–inorganic nanoplatform, especially for cancer treatments. [Image: see text]
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spelling pubmed-50348252016-10-03 Virus‐Surface‐Mimicking Surface Clustering of AuNPs onto DNA‐Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster‐Induced NIR Photothermal Therapy Jia, Hui‐Zhen Chen, Wei‐Hai Wang, Xuli Lei, Qi Yin, Wei‐Na Wang, Yan Zhuo, Ren‐Xi Feng, Jun Zhang, Xian‐Zheng Adv Sci (Weinh) Communications Virus‐surface‐mimicking decoration of deoxyribonucleic acid (DNA)‐entrapped polymeric nanoparticle with AuNPs is demonstrated to lead to enhanced cellular uptake, improved gene transfection, and particularly efficient near‐infrared photothermal therapy that cannot be achieved by both of them separately. This hybrid nanosystem represents a novel paradigm of multipurpose organic–inorganic nanoplatform, especially for cancer treatments. [Image: see text] John Wiley and Sons Inc. 2015-07-14 /pmc/articles/PMC5034825/ /pubmed/27708995 http://dx.doi.org/10.1002/advs.201500108 Text en © 2015 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Jia, Hui‐Zhen
Chen, Wei‐Hai
Wang, Xuli
Lei, Qi
Yin, Wei‐Na
Wang, Yan
Zhuo, Ren‐Xi
Feng, Jun
Zhang, Xian‐Zheng
Virus‐Surface‐Mimicking Surface Clustering of AuNPs onto DNA‐Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster‐Induced NIR Photothermal Therapy
title Virus‐Surface‐Mimicking Surface Clustering of AuNPs onto DNA‐Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster‐Induced NIR Photothermal Therapy
title_full Virus‐Surface‐Mimicking Surface Clustering of AuNPs onto DNA‐Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster‐Induced NIR Photothermal Therapy
title_fullStr Virus‐Surface‐Mimicking Surface Clustering of AuNPs onto DNA‐Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster‐Induced NIR Photothermal Therapy
title_full_unstemmed Virus‐Surface‐Mimicking Surface Clustering of AuNPs onto DNA‐Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster‐Induced NIR Photothermal Therapy
title_short Virus‐Surface‐Mimicking Surface Clustering of AuNPs onto DNA‐Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster‐Induced NIR Photothermal Therapy
title_sort virus‐surface‐mimicking surface clustering of aunps onto dna‐entrapped polymeric nanoparticle for enhanced cellular internalization and nanocluster‐induced nir photothermal therapy
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034825/
https://www.ncbi.nlm.nih.gov/pubmed/27708995
http://dx.doi.org/10.1002/advs.201500108
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