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Multi‐omic profiling of EPO‐producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production
Chinese hamster ovary (CHO) cells are the preferred production host for many therapeutic proteins. The production of heterologous proteins in CHO cells imposes a burden on the host cell metabolism and impact cellular physiology on a global scale. In this work, a multi‐omics approach was applied to s...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034845/ https://www.ncbi.nlm.nih.gov/pubmed/25995028 http://dx.doi.org/10.1002/bit.25652 |