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Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies
Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034882/ https://www.ncbi.nlm.nih.gov/pubmed/27688707 http://dx.doi.org/10.4137/CIN.S40301 |
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author | Long, Nguyen Phuoc Lee, Wun Jun Huy, Nguyen Truong Lee, Seul Ji Park, Jeong Hill Kwon, Sung Won |
author_facet | Long, Nguyen Phuoc Lee, Wun Jun Huy, Nguyen Truong Lee, Seul Ji Park, Jeong Hill Kwon, Sung Won |
author_sort | Long, Nguyen Phuoc |
collection | PubMed |
description | Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prognostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation. |
format | Online Article Text |
id | pubmed-5034882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-50348822016-09-29 Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies Long, Nguyen Phuoc Lee, Wun Jun Huy, Nguyen Truong Lee, Seul Ji Park, Jeong Hill Kwon, Sung Won Cancer Inform Original Research Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prognostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation. Libertas Academica 2016-09-22 /pmc/articles/PMC5034882/ /pubmed/27688707 http://dx.doi.org/10.4137/CIN.S40301 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 license. |
spellingShingle | Original Research Long, Nguyen Phuoc Lee, Wun Jun Huy, Nguyen Truong Lee, Seul Ji Park, Jeong Hill Kwon, Sung Won Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies |
title | Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies |
title_full | Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies |
title_fullStr | Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies |
title_full_unstemmed | Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies |
title_short | Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies |
title_sort | novel biomarker candidates for colorectal cancer metastasis: a meta-analysis of in vitro studies |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034882/ https://www.ncbi.nlm.nih.gov/pubmed/27688707 http://dx.doi.org/10.4137/CIN.S40301 |
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