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Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies

Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysi...

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Autores principales: Long, Nguyen Phuoc, Lee, Wun Jun, Huy, Nguyen Truong, Lee, Seul Ji, Park, Jeong Hill, Kwon, Sung Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034882/
https://www.ncbi.nlm.nih.gov/pubmed/27688707
http://dx.doi.org/10.4137/CIN.S40301
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author Long, Nguyen Phuoc
Lee, Wun Jun
Huy, Nguyen Truong
Lee, Seul Ji
Park, Jeong Hill
Kwon, Sung Won
author_facet Long, Nguyen Phuoc
Lee, Wun Jun
Huy, Nguyen Truong
Lee, Seul Ji
Park, Jeong Hill
Kwon, Sung Won
author_sort Long, Nguyen Phuoc
collection PubMed
description Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prognostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation.
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spelling pubmed-50348822016-09-29 Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies Long, Nguyen Phuoc Lee, Wun Jun Huy, Nguyen Truong Lee, Seul Ji Park, Jeong Hill Kwon, Sung Won Cancer Inform Original Research Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prognostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation. Libertas Academica 2016-09-22 /pmc/articles/PMC5034882/ /pubmed/27688707 http://dx.doi.org/10.4137/CIN.S40301 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 license.
spellingShingle Original Research
Long, Nguyen Phuoc
Lee, Wun Jun
Huy, Nguyen Truong
Lee, Seul Ji
Park, Jeong Hill
Kwon, Sung Won
Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies
title Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies
title_full Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies
title_fullStr Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies
title_full_unstemmed Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies
title_short Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies
title_sort novel biomarker candidates for colorectal cancer metastasis: a meta-analysis of in vitro studies
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034882/
https://www.ncbi.nlm.nih.gov/pubmed/27688707
http://dx.doi.org/10.4137/CIN.S40301
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