Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide
2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pergamon Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034901/ https://www.ncbi.nlm.nih.gov/pubmed/27518217 http://dx.doi.org/10.1016/j.apradiso.2016.07.023 |
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author | Morris, Olivia Gregory, J. Kadirvel, M. Henderson, Fiona Blykers, A. McMahon, Adam Taylor, Mark Allsop, David Allan, Stuart Grigg, J. Boutin, Herve Prenant, Christian |
author_facet | Morris, Olivia Gregory, J. Kadirvel, M. Henderson, Fiona Blykers, A. McMahon, Adam Taylor, Mark Allsop, David Allan, Stuart Grigg, J. Boutin, Herve Prenant, Christian |
author_sort | Morris, Olivia |
collection | PubMed |
description | 2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [(18)F]RI-OR2-TAT has been measured in Wistar rats. |
format | Online Article Text |
id | pubmed-5034901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Pergamon Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-50349012016-10-01 Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide Morris, Olivia Gregory, J. Kadirvel, M. Henderson, Fiona Blykers, A. McMahon, Adam Taylor, Mark Allsop, David Allan, Stuart Grigg, J. Boutin, Herve Prenant, Christian Appl Radiat Isot Article 2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [(18)F]RI-OR2-TAT has been measured in Wistar rats. Pergamon Press 2016-10 /pmc/articles/PMC5034901/ /pubmed/27518217 http://dx.doi.org/10.1016/j.apradiso.2016.07.023 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Morris, Olivia Gregory, J. Kadirvel, M. Henderson, Fiona Blykers, A. McMahon, Adam Taylor, Mark Allsop, David Allan, Stuart Grigg, J. Boutin, Herve Prenant, Christian Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide |
title | Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide |
title_full | Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide |
title_fullStr | Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide |
title_full_unstemmed | Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide |
title_short | Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide |
title_sort | development & automation of a novel [(18)f]f prosthetic group, 2-[(18)f]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised aβ peptide |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034901/ https://www.ncbi.nlm.nih.gov/pubmed/27518217 http://dx.doi.org/10.1016/j.apradiso.2016.07.023 |
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