Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide

2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab...

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Autores principales: Morris, Olivia, Gregory, J., Kadirvel, M., Henderson, Fiona, Blykers, A., McMahon, Adam, Taylor, Mark, Allsop, David, Allan, Stuart, Grigg, J., Boutin, Herve, Prenant, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034901/
https://www.ncbi.nlm.nih.gov/pubmed/27518217
http://dx.doi.org/10.1016/j.apradiso.2016.07.023
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author Morris, Olivia
Gregory, J.
Kadirvel, M.
Henderson, Fiona
Blykers, A.
McMahon, Adam
Taylor, Mark
Allsop, David
Allan, Stuart
Grigg, J.
Boutin, Herve
Prenant, Christian
author_facet Morris, Olivia
Gregory, J.
Kadirvel, M.
Henderson, Fiona
Blykers, A.
McMahon, Adam
Taylor, Mark
Allsop, David
Allan, Stuart
Grigg, J.
Boutin, Herve
Prenant, Christian
author_sort Morris, Olivia
collection PubMed
description 2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [(18)F]RI-OR2-TAT has been measured in Wistar rats.
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spelling pubmed-50349012016-10-01 Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide Morris, Olivia Gregory, J. Kadirvel, M. Henderson, Fiona Blykers, A. McMahon, Adam Taylor, Mark Allsop, David Allan, Stuart Grigg, J. Boutin, Herve Prenant, Christian Appl Radiat Isot Article 2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [(18)F]RI-OR2-TAT has been measured in Wistar rats. Pergamon Press 2016-10 /pmc/articles/PMC5034901/ /pubmed/27518217 http://dx.doi.org/10.1016/j.apradiso.2016.07.023 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Morris, Olivia
Gregory, J.
Kadirvel, M.
Henderson, Fiona
Blykers, A.
McMahon, Adam
Taylor, Mark
Allsop, David
Allan, Stuart
Grigg, J.
Boutin, Herve
Prenant, Christian
Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide
title Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide
title_full Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide
title_fullStr Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide
title_full_unstemmed Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide
title_short Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide
title_sort development & automation of a novel [(18)f]f prosthetic group, 2-[(18)f]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised aβ peptide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034901/
https://www.ncbi.nlm.nih.gov/pubmed/27518217
http://dx.doi.org/10.1016/j.apradiso.2016.07.023
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