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Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation

OBJECTIVES: To determine significance and sensitivity of the Free to Total prostate specific antigen (PSA) ratio (%fPSA) in diagnosis of prostate cancer and to correlate its sensitivity and specificity with diagnosis. METHODS: Research included 220 patients, who had indication for biopsy (Clinic for...

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Autores principales: Prcic, Alden, Begic, Edin, Hiros, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AVICENA, d.o.o., Sarajevo 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034994/
https://www.ncbi.nlm.nih.gov/pubmed/27703291
http://dx.doi.org/10.5455/medarh.2016.70.288-292
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author Prcic, Alden
Begic, Edin
Hiros, Mustafa
author_facet Prcic, Alden
Begic, Edin
Hiros, Mustafa
author_sort Prcic, Alden
collection PubMed
description OBJECTIVES: To determine significance and sensitivity of the Free to Total prostate specific antigen (PSA) ratio (%fPSA) in diagnosis of prostate cancer and to correlate its sensitivity and specificity with diagnosis. METHODS: Research included 220 patients, who had indication for biopsy (Clinic for Urology, University Clinical Center Sarajevo). RESULTS: Average age of patients was 64.6 ± 8.1 years. Kruskal Wallis test indicates that there is a significant difference in age in relation to the diagnosis (KW χ(2)=12.508; p=0.006). The correlation between the %fPSA level and diagnosis is positive and statistically significant (r=0.211; p=0.002) in the sense that cancer patients have the lowest %fPSA. Analysis of the sensitivity at 95% specificity of %fPSA compared to particular diagnosis shows the highest sensitivity for prostate cancer - 20.61% (8.35-31.02) with statistically significant AUC p<0.05. Analysis of %fPSA test in detecting prostate cancer, at cut-off values ≤ 0.16, shows a sensitivity of 72.3% and specificity of 50.4 (at cut-off values <0.07, sensitivity is 8.4%, and specificity is 97.8%). CONCLUSION: PSA is organ specific but not cancer specific marker, whose total value, as well as the %fPSA serve as a basis, with a digitorectal exam, in the detection of prostate cancer. By increasing the cut-off values sensitivity of %fPSA increases and specificity decreases. %fPSA has a relative importance in the detection of prostate cancer, and should not be used as a guideline, without prior clinical examination.
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spelling pubmed-50349942016-10-04 Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation Prcic, Alden Begic, Edin Hiros, Mustafa Med Arch Original Paper OBJECTIVES: To determine significance and sensitivity of the Free to Total prostate specific antigen (PSA) ratio (%fPSA) in diagnosis of prostate cancer and to correlate its sensitivity and specificity with diagnosis. METHODS: Research included 220 patients, who had indication for biopsy (Clinic for Urology, University Clinical Center Sarajevo). RESULTS: Average age of patients was 64.6 ± 8.1 years. Kruskal Wallis test indicates that there is a significant difference in age in relation to the diagnosis (KW χ(2)=12.508; p=0.006). The correlation between the %fPSA level and diagnosis is positive and statistically significant (r=0.211; p=0.002) in the sense that cancer patients have the lowest %fPSA. Analysis of the sensitivity at 95% specificity of %fPSA compared to particular diagnosis shows the highest sensitivity for prostate cancer - 20.61% (8.35-31.02) with statistically significant AUC p<0.05. Analysis of %fPSA test in detecting prostate cancer, at cut-off values ≤ 0.16, shows a sensitivity of 72.3% and specificity of 50.4 (at cut-off values <0.07, sensitivity is 8.4%, and specificity is 97.8%). CONCLUSION: PSA is organ specific but not cancer specific marker, whose total value, as well as the %fPSA serve as a basis, with a digitorectal exam, in the detection of prostate cancer. By increasing the cut-off values sensitivity of %fPSA increases and specificity decreases. %fPSA has a relative importance in the detection of prostate cancer, and should not be used as a guideline, without prior clinical examination. AVICENA, d.o.o., Sarajevo 2016-07-27 2016-08 /pmc/articles/PMC5034994/ /pubmed/27703291 http://dx.doi.org/10.5455/medarh.2016.70.288-292 Text en Copyright: © 2016 Alden Prcic, Edin Begic, and Mustafa Hiros http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Prcic, Alden
Begic, Edin
Hiros, Mustafa
Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation
title Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation
title_full Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation
title_fullStr Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation
title_full_unstemmed Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation
title_short Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation
title_sort actual contribution of free to total psa ratio in prostate diseases differentiation
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034994/
https://www.ncbi.nlm.nih.gov/pubmed/27703291
http://dx.doi.org/10.5455/medarh.2016.70.288-292
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