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Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation
OBJECTIVES: To determine significance and sensitivity of the Free to Total prostate specific antigen (PSA) ratio (%fPSA) in diagnosis of prostate cancer and to correlate its sensitivity and specificity with diagnosis. METHODS: Research included 220 patients, who had indication for biopsy (Clinic for...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AVICENA, d.o.o., Sarajevo
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034994/ https://www.ncbi.nlm.nih.gov/pubmed/27703291 http://dx.doi.org/10.5455/medarh.2016.70.288-292 |
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author | Prcic, Alden Begic, Edin Hiros, Mustafa |
author_facet | Prcic, Alden Begic, Edin Hiros, Mustafa |
author_sort | Prcic, Alden |
collection | PubMed |
description | OBJECTIVES: To determine significance and sensitivity of the Free to Total prostate specific antigen (PSA) ratio (%fPSA) in diagnosis of prostate cancer and to correlate its sensitivity and specificity with diagnosis. METHODS: Research included 220 patients, who had indication for biopsy (Clinic for Urology, University Clinical Center Sarajevo). RESULTS: Average age of patients was 64.6 ± 8.1 years. Kruskal Wallis test indicates that there is a significant difference in age in relation to the diagnosis (KW χ(2)=12.508; p=0.006). The correlation between the %fPSA level and diagnosis is positive and statistically significant (r=0.211; p=0.002) in the sense that cancer patients have the lowest %fPSA. Analysis of the sensitivity at 95% specificity of %fPSA compared to particular diagnosis shows the highest sensitivity for prostate cancer - 20.61% (8.35-31.02) with statistically significant AUC p<0.05. Analysis of %fPSA test in detecting prostate cancer, at cut-off values ≤ 0.16, shows a sensitivity of 72.3% and specificity of 50.4 (at cut-off values <0.07, sensitivity is 8.4%, and specificity is 97.8%). CONCLUSION: PSA is organ specific but not cancer specific marker, whose total value, as well as the %fPSA serve as a basis, with a digitorectal exam, in the detection of prostate cancer. By increasing the cut-off values sensitivity of %fPSA increases and specificity decreases. %fPSA has a relative importance in the detection of prostate cancer, and should not be used as a guideline, without prior clinical examination. |
format | Online Article Text |
id | pubmed-5034994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | AVICENA, d.o.o., Sarajevo |
record_format | MEDLINE/PubMed |
spelling | pubmed-50349942016-10-04 Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation Prcic, Alden Begic, Edin Hiros, Mustafa Med Arch Original Paper OBJECTIVES: To determine significance and sensitivity of the Free to Total prostate specific antigen (PSA) ratio (%fPSA) in diagnosis of prostate cancer and to correlate its sensitivity and specificity with diagnosis. METHODS: Research included 220 patients, who had indication for biopsy (Clinic for Urology, University Clinical Center Sarajevo). RESULTS: Average age of patients was 64.6 ± 8.1 years. Kruskal Wallis test indicates that there is a significant difference in age in relation to the diagnosis (KW χ(2)=12.508; p=0.006). The correlation between the %fPSA level and diagnosis is positive and statistically significant (r=0.211; p=0.002) in the sense that cancer patients have the lowest %fPSA. Analysis of the sensitivity at 95% specificity of %fPSA compared to particular diagnosis shows the highest sensitivity for prostate cancer - 20.61% (8.35-31.02) with statistically significant AUC p<0.05. Analysis of %fPSA test in detecting prostate cancer, at cut-off values ≤ 0.16, shows a sensitivity of 72.3% and specificity of 50.4 (at cut-off values <0.07, sensitivity is 8.4%, and specificity is 97.8%). CONCLUSION: PSA is organ specific but not cancer specific marker, whose total value, as well as the %fPSA serve as a basis, with a digitorectal exam, in the detection of prostate cancer. By increasing the cut-off values sensitivity of %fPSA increases and specificity decreases. %fPSA has a relative importance in the detection of prostate cancer, and should not be used as a guideline, without prior clinical examination. AVICENA, d.o.o., Sarajevo 2016-07-27 2016-08 /pmc/articles/PMC5034994/ /pubmed/27703291 http://dx.doi.org/10.5455/medarh.2016.70.288-292 Text en Copyright: © 2016 Alden Prcic, Edin Begic, and Mustafa Hiros http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Prcic, Alden Begic, Edin Hiros, Mustafa Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation |
title | Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation |
title_full | Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation |
title_fullStr | Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation |
title_full_unstemmed | Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation |
title_short | Actual Contribution of Free to Total PSA Ratio in Prostate Diseases Differentiation |
title_sort | actual contribution of free to total psa ratio in prostate diseases differentiation |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034994/ https://www.ncbi.nlm.nih.gov/pubmed/27703291 http://dx.doi.org/10.5455/medarh.2016.70.288-292 |
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