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IL6-174 G>C Polymorphism (rs1800795) Association with Late Effects of Low Dose Radiation Exposure in the Portuguese Tinea Capitis Cohort

Head and neck cancers, and cardiovascular disease have been described as late effects of low dose radiation (LDR) exposure, namely in tinea capitis cohorts. In addition to radiation dose, gender and younger age at exposure, the genetic background might be involved in the susceptibility to LDR late e...

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Autores principales: Boaventura, Paula, Durães, Cecília, Mendes, Adélia, Costa, Natália Rios, Chora, Inês, Ferreira, Sara, Araújo, Emanuel, Lopes, Pedro, Rosa, Gilberto, Marques, Pedro, Bettencourt, Paulo, Oliveira, Inês, Costa, Francisco, Ramos, Isabel, Teles, Maria José, Guimarães, João Tiago, Sobrinho-Simões, Manuel, Soares, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035001/
https://www.ncbi.nlm.nih.gov/pubmed/27662210
http://dx.doi.org/10.1371/journal.pone.0163474
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author Boaventura, Paula
Durães, Cecília
Mendes, Adélia
Costa, Natália Rios
Chora, Inês
Ferreira, Sara
Araújo, Emanuel
Lopes, Pedro
Rosa, Gilberto
Marques, Pedro
Bettencourt, Paulo
Oliveira, Inês
Costa, Francisco
Ramos, Isabel
Teles, Maria José
Guimarães, João Tiago
Sobrinho-Simões, Manuel
Soares, Paula
author_facet Boaventura, Paula
Durães, Cecília
Mendes, Adélia
Costa, Natália Rios
Chora, Inês
Ferreira, Sara
Araújo, Emanuel
Lopes, Pedro
Rosa, Gilberto
Marques, Pedro
Bettencourt, Paulo
Oliveira, Inês
Costa, Francisco
Ramos, Isabel
Teles, Maria José
Guimarães, João Tiago
Sobrinho-Simões, Manuel
Soares, Paula
author_sort Boaventura, Paula
collection PubMed
description Head and neck cancers, and cardiovascular disease have been described as late effects of low dose radiation (LDR) exposure, namely in tinea capitis cohorts. In addition to radiation dose, gender and younger age at exposure, the genetic background might be involved in the susceptibility to LDR late effects. The -174 G>C (rs1800795) SNP in IL6 has been associated with cancer and cardiovascular disease, nevertheless this association is still controversial. We assessed the association of the IL6-174 G>C SNP with LDR effects such as thyroid carcinoma, basal cell carcinoma and carotid atherosclerosis in the Portuguese tinea capitis cohort. The IL6-174 G>C SNP was genotyped in 1269 individuals formerly irradiated for tinea capitis. This sampling group included thyroid cancer (n = 36), basal cell carcinoma (n = 113) and cases without thyroid or basal cell carcinoma (1120). A subgroup was assessed for atherosclerosis by ultrasonography (n = 379) and included matched controls (n = 222). Genotypes were discriminated by real-time PCR using a TaqMan SNP genotyping assay. In the irradiated group, we observed that the CC genotype was significantly associated with carotid plaque risk, both in the genotypic (OR = 3.57, CI = 1.60–7.95, p-value = 0.002) and in the recessive (OR = 3.02, CI = 1.42–6.42, p-value = 0.004) models. Irradiation alone was not a risk factor for carotid atherosclerosis. We did not find a significant association of the IL6-174 C allele with thyroid carcinoma or basal cell carcinoma risk. The IL6-174 CC genotype confers a three-fold risk for carotid atherosclerotic disease suggesting it may represent a genetic susceptibility factor in the LDR context.
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spelling pubmed-50350012016-10-10 IL6-174 G>C Polymorphism (rs1800795) Association with Late Effects of Low Dose Radiation Exposure in the Portuguese Tinea Capitis Cohort Boaventura, Paula Durães, Cecília Mendes, Adélia Costa, Natália Rios Chora, Inês Ferreira, Sara Araújo, Emanuel Lopes, Pedro Rosa, Gilberto Marques, Pedro Bettencourt, Paulo Oliveira, Inês Costa, Francisco Ramos, Isabel Teles, Maria José Guimarães, João Tiago Sobrinho-Simões, Manuel Soares, Paula PLoS One Research Article Head and neck cancers, and cardiovascular disease have been described as late effects of low dose radiation (LDR) exposure, namely in tinea capitis cohorts. In addition to radiation dose, gender and younger age at exposure, the genetic background might be involved in the susceptibility to LDR late effects. The -174 G>C (rs1800795) SNP in IL6 has been associated with cancer and cardiovascular disease, nevertheless this association is still controversial. We assessed the association of the IL6-174 G>C SNP with LDR effects such as thyroid carcinoma, basal cell carcinoma and carotid atherosclerosis in the Portuguese tinea capitis cohort. The IL6-174 G>C SNP was genotyped in 1269 individuals formerly irradiated for tinea capitis. This sampling group included thyroid cancer (n = 36), basal cell carcinoma (n = 113) and cases without thyroid or basal cell carcinoma (1120). A subgroup was assessed for atherosclerosis by ultrasonography (n = 379) and included matched controls (n = 222). Genotypes were discriminated by real-time PCR using a TaqMan SNP genotyping assay. In the irradiated group, we observed that the CC genotype was significantly associated with carotid plaque risk, both in the genotypic (OR = 3.57, CI = 1.60–7.95, p-value = 0.002) and in the recessive (OR = 3.02, CI = 1.42–6.42, p-value = 0.004) models. Irradiation alone was not a risk factor for carotid atherosclerosis. We did not find a significant association of the IL6-174 C allele with thyroid carcinoma or basal cell carcinoma risk. The IL6-174 CC genotype confers a three-fold risk for carotid atherosclerotic disease suggesting it may represent a genetic susceptibility factor in the LDR context. Public Library of Science 2016-09-23 /pmc/articles/PMC5035001/ /pubmed/27662210 http://dx.doi.org/10.1371/journal.pone.0163474 Text en © 2016 Boaventura et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Boaventura, Paula
Durães, Cecília
Mendes, Adélia
Costa, Natália Rios
Chora, Inês
Ferreira, Sara
Araújo, Emanuel
Lopes, Pedro
Rosa, Gilberto
Marques, Pedro
Bettencourt, Paulo
Oliveira, Inês
Costa, Francisco
Ramos, Isabel
Teles, Maria José
Guimarães, João Tiago
Sobrinho-Simões, Manuel
Soares, Paula
IL6-174 G>C Polymorphism (rs1800795) Association with Late Effects of Low Dose Radiation Exposure in the Portuguese Tinea Capitis Cohort
title IL6-174 G>C Polymorphism (rs1800795) Association with Late Effects of Low Dose Radiation Exposure in the Portuguese Tinea Capitis Cohort
title_full IL6-174 G>C Polymorphism (rs1800795) Association with Late Effects of Low Dose Radiation Exposure in the Portuguese Tinea Capitis Cohort
title_fullStr IL6-174 G>C Polymorphism (rs1800795) Association with Late Effects of Low Dose Radiation Exposure in the Portuguese Tinea Capitis Cohort
title_full_unstemmed IL6-174 G>C Polymorphism (rs1800795) Association with Late Effects of Low Dose Radiation Exposure in the Portuguese Tinea Capitis Cohort
title_short IL6-174 G>C Polymorphism (rs1800795) Association with Late Effects of Low Dose Radiation Exposure in the Portuguese Tinea Capitis Cohort
title_sort il6-174 g>c polymorphism (rs1800795) association with late effects of low dose radiation exposure in the portuguese tinea capitis cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035001/
https://www.ncbi.nlm.nih.gov/pubmed/27662210
http://dx.doi.org/10.1371/journal.pone.0163474
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