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Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF)

Period 2-mutant mice (Per2(m/m)), which possess a circadian dysfunction, recapitulate the retinal vascular phenotype similar to diabetic retinopathy (DR). The vascular dysfunction in Per2(m/m) is associated with an increase in connective tissue growth factor (CTGF/CCN2). At the molecular level, CTGF...

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Detalles Bibliográficos
Autores principales:	Jadhav, Vaishnavi, Luo, Qianyi, M. Dominguez, James, Al-Sabah, Jude, Chaqour, Brahim, Grant, Maria B., Bhatwadekar, Ashay D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035004/ https://www.ncbi.nlm.nih.gov/pubmed/27662578 http://dx.doi.org/10.1371/journal.pone.0163367

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