Binding and Inhibition of Spermidine Synthase from Plasmodium falciparum and Implications for In Vitro Inhibitor Testing

The aminopropyltransferase spermidine synthase (SpdS) is a promising drug target in cancer and in protozoan diseases including malaria. Plasmodium falciparum SpdS (PfSpdS) transfers the aminopropyl group of decarboxylated S-adenosylmethionine (dcAdoMet) to putrescine or to spermidine to form spermid...

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Detalles Bibliográficos
Autores principales: Sprenger, Janina, Carey, Jannette, Svensson, Bo, Wengel, Verena, Persson, Lo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035006/
https://www.ncbi.nlm.nih.gov/pubmed/27661085
http://dx.doi.org/10.1371/journal.pone.0163442

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