Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors

BACKGROUND: Variation in the carboxylesterase 1 gene (CES1) may contribute to the efficacy of ACEIs. Accordingly, we examined the impact of CES1 variants on plasma angiotensin II (ATII)/angiotensin I (ATI) ratio in patients with congestive heart failure (CHF) that underwent ACEI dose titrations. Fiv...

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Detalles Bibliográficos
Autores principales: Nelveg-Kristensen, Karl Emil, Bie, Peter, Ferrero, Laura, Bjerre, Ditte, Bruun, Niels E., Egfjord, Martin, Rasmussen, Henrik B., Hansen, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035013/
https://www.ncbi.nlm.nih.gov/pubmed/27662362
http://dx.doi.org/10.1371/journal.pone.0163341

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