Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels

The neurotransmitter GABA has been recently identified as a potent immunosuppressive agent that targets both innate and adaptive immune systems and prevents disease progression of several autoimmunity models. Mesenchymal stem cells (MSCs) are self-renewing progenitor cells that differentiate into va...

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Detalles Bibliográficos
Autores principales: Urrutia, Mariana, Fernández, Sebastián, González, Marisol, Vilches, Rodrigo, Rojas, Pablo, Vásquez, Manuel, Kurte, Mónica, Vega-Letter, Ana María, Carrión, Flavio, Figueroa, Fernando, Rojas, Patricio, Irarrázabal, Carlos, Fuentealba, Rodrigo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035029/
https://www.ncbi.nlm.nih.gov/pubmed/27662193
http://dx.doi.org/10.1371/journal.pone.0163735

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