Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy

Diabetes elevates matrix metalloproteinase-9 (MMP-9) in the retina and its capillary cells, and activated MMP-9 damages mitochondria, accelerating retinal capillary cell apoptosis, a phenomenon which precedes the development of retinopathy. Diabetes also favors epigenetic modifications regulating ex...

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Detalles Bibliográficos
Autores principales: Kowluru, Renu A., Shen, Yang, Mishra, Manish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035192/
https://www.ncbi.nlm.nih.gov/pubmed/27454437
http://dx.doi.org/10.1038/labinvest.2016.78

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