Cargando…
Establishing a complementary diagnostic for anti-PD-1 immune checkpoint inhibitor therapy
The role of tumor PD-L1 expression was investigated across the nivolumab clinical development program. Phase III nivolumab trials have shown that patients with tumors not expressing PD-L1 may benefit; therefore, testing is not required to select patients for therapy. The Dako PD-L1 IHC 28-8 pharmDx...
Autores principales: | Novotny, J. F., Cogswell, J., Inzunza, H., Harbison, C., Horak, C., Averbuch, S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035792/ https://www.ncbi.nlm.nih.gov/pubmed/27502705 http://dx.doi.org/10.1093/annonc/mdw288 |
Ejemplares similares
-
Avelumab: clinical trial innovation and collaboration to advance anti-PD-L1 immunotherapy
por: Chin, K., et al.
Publicado: (2017) -
Pembrolizumab KEYNOTE-001: an adaptive study leading to accelerated approval for two indications and a companion diagnostic
por: Kang, S. P., et al.
Publicado: (2017) -
Joint adolescent–adult early phase clinical trials to improve access to new drugs for adolescents with cancer: proposals from the multi-stakeholder platform—ACCELERATE
por: Gaspar, N, et al.
Publicado: (2018) -
Discovery and development of novel therapies in advanced breast cancer: rapid development of ribociclib
por: Germa, C., et al.
Publicado: (2017) -
Cross-over—it's a feature, not a bug
por: Engelsberg, A.
Publicado: (2015)