The Life-Cycle of the HIV-1 Gag–RNA Complex

Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process requiring the recruitment of viral and cellular components to the plasma membrane for assembly into infectious particles. This review highlights the recent process of understanding the selection of the genomic RNA...

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Detalles Bibliográficos
Autores principales: Mailler, Elodie, Bernacchi, Serena, Marquet, Roland, Paillart, Jean-Christophe, Vivet-Boudou, Valérie, Smyth, Redmond P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035962/
https://www.ncbi.nlm.nih.gov/pubmed/27626439
http://dx.doi.org/10.3390/v8090248
Descripción
Sumario:Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process requiring the recruitment of viral and cellular components to the plasma membrane for assembly into infectious particles. This review highlights the recent process of understanding the selection of the genomic RNA (gRNA) by the viral Pr55(Gag) precursor polyprotein, and the processes leading to its incorporation into viral particles.

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