TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A

The members of tripartite-motif containing (TRIM) protein participate in various cellular processes and play an important role in host antiviral function. TRIM proteins exert their antiviral activity either directly by degrading viral proteins through their E3 ligase activity, or indirectly by promo...

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Detalles Bibliográficos
Autores principales: Fan, Wenchun, Wu, Mengge, Qian, Suhong, Zhou, Yun, Chen, Huanchun, Li, Xiangmin, Qian, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035999/
https://www.ncbi.nlm.nih.gov/pubmed/27667714
http://dx.doi.org/10.1038/srep33698
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author Fan, Wenchun
Wu, Mengge
Qian, Suhong
Zhou, Yun
Chen, Huanchun
Li, Xiangmin
Qian, Ping
author_facet Fan, Wenchun
Wu, Mengge
Qian, Suhong
Zhou, Yun
Chen, Huanchun
Li, Xiangmin
Qian, Ping
author_sort Fan, Wenchun
collection PubMed
description The members of tripartite-motif containing (TRIM) protein participate in various cellular processes and play an important role in host antiviral function. TRIM proteins exert their antiviral activity either directly by degrading viral proteins through their E3 ligase activity, or indirectly by promoting host innate immunity. This study demonstrated for the first time that TRIM52 is a novel antiviral TRIM protein against Japanese encephalitis virus (JEV) infection. Overexpression of TRIM52 restricted JEV replication in BHK-21 and 293T cells. In addition, JEV nonstructural protein 2A (NS2A) is a protein that interacts with TRIM52. Their interaction degraded NS2A in a proteasome-dependent manner via the E3 ligase activity of TRIM52. Thus, TRIM52 is a novel antiviral TRIM protein, and it exerted antiviral activity against JEV infection by targeting and degrading viral NS2A.
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spelling pubmed-50359992016-09-30 TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A Fan, Wenchun Wu, Mengge Qian, Suhong Zhou, Yun Chen, Huanchun Li, Xiangmin Qian, Ping Sci Rep Article The members of tripartite-motif containing (TRIM) protein participate in various cellular processes and play an important role in host antiviral function. TRIM proteins exert their antiviral activity either directly by degrading viral proteins through their E3 ligase activity, or indirectly by promoting host innate immunity. This study demonstrated for the first time that TRIM52 is a novel antiviral TRIM protein against Japanese encephalitis virus (JEV) infection. Overexpression of TRIM52 restricted JEV replication in BHK-21 and 293T cells. In addition, JEV nonstructural protein 2A (NS2A) is a protein that interacts with TRIM52. Their interaction degraded NS2A in a proteasome-dependent manner via the E3 ligase activity of TRIM52. Thus, TRIM52 is a novel antiviral TRIM protein, and it exerted antiviral activity against JEV infection by targeting and degrading viral NS2A. Nature Publishing Group 2016-09-26 /pmc/articles/PMC5035999/ /pubmed/27667714 http://dx.doi.org/10.1038/srep33698 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Fan, Wenchun
Wu, Mengge
Qian, Suhong
Zhou, Yun
Chen, Huanchun
Li, Xiangmin
Qian, Ping
TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A
title TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A
title_full TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A
title_fullStr TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A
title_full_unstemmed TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A
title_short TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A
title_sort trim52 inhibits japanese encephalitis virus replication by degrading the viral ns2a
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035999/
https://www.ncbi.nlm.nih.gov/pubmed/27667714
http://dx.doi.org/10.1038/srep33698
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