The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

Cytosine mutations within TCA/T motifs are common in cancer. A likely cause is the DNA cytosine deaminase APOBEC3B (A3B). However, A3B-null breast tumours still have this mutational bias. Here we show that APOBEC3H haplotype I (A3H-I) provides a likely solution to this paradox. A3B-null tumours with...

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Detalles Bibliográficos
Autores principales: Starrett, Gabriel J., Luengas, Elizabeth M., McCann, Jennifer L., Ebrahimi, Diako, Temiz, Nuri A., Love, Robin P., Feng, Yuqing, Adolph, Madison B., Chelico, Linda, Law, Emily K., Carpenter, Michael A., Harris, Reuben S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036005/
https://www.ncbi.nlm.nih.gov/pubmed/27650891
http://dx.doi.org/10.1038/ncomms12918

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