Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival

TBC1D10C is a protein previously demonstrated to bind and inhibit Ras and Calcineurin. In cardiomyocytes, also CaMKII is inhibited and all three targeted enzymes are known to promote maladaptive cardiomyocyte hypertrophy. Here, in accordance with lack of Calcineurin inhibition in vivo, we did not ob...

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Detalles Bibliográficos
Autores principales: Volland, Cornelia, Bremer, Sebastian, Hellenkamp, Kristian, Hartmann, Nico, Dybkova, Nataliya, Khadjeh, Sara, Kutschenko, Anna, Liebetanz, David, Wagner, Stefan, Unsöld, Bernhard, Didié, Michael, Toischer, Karl, Sossalla, Samuel, Hasenfuß, Gerd, Seidler, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036039/
https://www.ncbi.nlm.nih.gov/pubmed/27667030
http://dx.doi.org/10.1038/srep33853

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