Histone Deacetylase Inhibitor Phenylbutyrate Exaggerates Heart Failure in Pressure Overloaded Mice independently of HDAC inhibition

4-Sodium phenylbutyrate (PBA) has been reported to inhibit endoplasmic reticulum stress and histone deacetylation (HDAC), both of which are novel therapeutic targets for cardiac hypertrophy and heart failure. However, it is unclear whether PBA can improve heart function. Here, we tested the effects...

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Detalles Bibliográficos
Autores principales: Ma, Jing, Luo, Tao, Zeng, Zhi, Fu, Haiying, Asano, Yoshihiro, Liao, Yulin, Minamino, Tetsuo, Kitakaze, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036044/
https://www.ncbi.nlm.nih.gov/pubmed/27667442
http://dx.doi.org/10.1038/srep34036

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