Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or sequencing errors?

Across independent cancer genomes it has been observed that some sites have been recurrently hit by single nucleotide variants (SNVs). Such recurrently hit sites might be either (i) drivers of cancer that are postively selected during oncogenesis, (ii) due to mutation rate variation, or (iii) due to...

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Detalles Bibliográficos
Autores principales: Smith, Thomas C.A., Carr, Antony M., Eyre-Walker, Adam C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036107/
https://www.ncbi.nlm.nih.gov/pubmed/27688957
http://dx.doi.org/10.7717/peerj.2391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036107/
https://www.ncbi.nlm.nih.gov/pubmed/27688957
http://dx.doi.org/10.7717/peerj.2391

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