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BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection
Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy (BKN) of the native kidneys has being increasingly recognized as a cause...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036119/ https://www.ncbi.nlm.nih.gov/pubmed/27683628 http://dx.doi.org/10.5500/wjt.v6.i3.472 |
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author | Vigil, Darlene Konstantinov, Nikifor K Barry, Marc Harford, Antonia M Servilla, Karen S Kim, Young Ho Sun, Yijuan Ganta, Kavitha Tzamaloukas, Antonios H |
author_facet | Vigil, Darlene Konstantinov, Nikifor K Barry, Marc Harford, Antonia M Servilla, Karen S Kim, Young Ho Sun, Yijuan Ganta, Kavitha Tzamaloukas, Antonios H |
author_sort | Vigil, Darlene |
collection | PubMed |
description | Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy (BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research. |
format | Online Article Text |
id | pubmed-5036119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-50361192016-09-28 BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection Vigil, Darlene Konstantinov, Nikifor K Barry, Marc Harford, Antonia M Servilla, Karen S Kim, Young Ho Sun, Yijuan Ganta, Kavitha Tzamaloukas, Antonios H World J Transplant Review Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy (BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research. Baishideng Publishing Group Inc 2016-09-24 2016-09-24 /pmc/articles/PMC5036119/ /pubmed/27683628 http://dx.doi.org/10.5500/wjt.v6.i3.472 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Review Vigil, Darlene Konstantinov, Nikifor K Barry, Marc Harford, Antonia M Servilla, Karen S Kim, Young Ho Sun, Yijuan Ganta, Kavitha Tzamaloukas, Antonios H BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection |
title | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection |
title_full | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection |
title_fullStr | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection |
title_full_unstemmed | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection |
title_short | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection |
title_sort | bk nephropathy in the native kidneys of patients with organ transplants: clinical spectrum of bk infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036119/ https://www.ncbi.nlm.nih.gov/pubmed/27683628 http://dx.doi.org/10.5500/wjt.v6.i3.472 |
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