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Representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour
The ability to change behavioural strategies in the face of a changing world has been linked to the integrity of medial prefrontal cortex (mPFC) function in several species. While recording studies have found that mPFC representations reflect the strategy being used, lesion studies suggest that mPFC...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036147/ https://www.ncbi.nlm.nih.gov/pubmed/27653278 http://dx.doi.org/10.1038/ncomms12830 |
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author | Powell, Nathaniel James Redish, A. David |
author_facet | Powell, Nathaniel James Redish, A. David |
author_sort | Powell, Nathaniel James |
collection | PubMed |
description | The ability to change behavioural strategies in the face of a changing world has been linked to the integrity of medial prefrontal cortex (mPFC) function in several species. While recording studies have found that mPFC representations reflect the strategy being used, lesion studies suggest that mPFC is necessary for changing strategy. Here we examine the relationship between representational changes in mPFC and behavioural strategy changes in the rat. We found that on tasks with a forced change in reward criterion, strategy-related representational transitions in mPFC occurred after animals learned that the reward contingency had changed, but before their behaviour changed. On tasks in which animals made their own strategic decisions, representational transitions in mPFC preceded changes in behaviour. These results suggest that mPFC does not merely reflect the action–selection policy of the animal, but rather that mPFC processes information related to a need for a change in strategy. |
format | Online Article Text |
id | pubmed-5036147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50361472016-10-04 Representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour Powell, Nathaniel James Redish, A. David Nat Commun Article The ability to change behavioural strategies in the face of a changing world has been linked to the integrity of medial prefrontal cortex (mPFC) function in several species. While recording studies have found that mPFC representations reflect the strategy being used, lesion studies suggest that mPFC is necessary for changing strategy. Here we examine the relationship between representational changes in mPFC and behavioural strategy changes in the rat. We found that on tasks with a forced change in reward criterion, strategy-related representational transitions in mPFC occurred after animals learned that the reward contingency had changed, but before their behaviour changed. On tasks in which animals made their own strategic decisions, representational transitions in mPFC preceded changes in behaviour. These results suggest that mPFC does not merely reflect the action–selection policy of the animal, but rather that mPFC processes information related to a need for a change in strategy. Nature Publishing Group 2016-09-22 /pmc/articles/PMC5036147/ /pubmed/27653278 http://dx.doi.org/10.1038/ncomms12830 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Powell, Nathaniel James Redish, A. David Representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour |
title | Representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour |
title_full | Representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour |
title_fullStr | Representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour |
title_full_unstemmed | Representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour |
title_short | Representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour |
title_sort | representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036147/ https://www.ncbi.nlm.nih.gov/pubmed/27653278 http://dx.doi.org/10.1038/ncomms12830 |
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