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GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation
Osteoporosis is an age-related disease that affects millions of people. Growth differentiation factor 11 (GDF11) is a secreted member of the transforming growth factor beta (TGF-β) superfamily. Deletion of Gdf11 has been shown to result in a skeletal anterior–posterior patterning disorder. Here we s...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036163/ https://www.ncbi.nlm.nih.gov/pubmed/27653144 http://dx.doi.org/10.1038/ncomms12794 |
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author | Liu, Weiqing Zhou, Liyan Zhou, Chenchen Zhang, Shiwen Jing, Junjun Xie, Liang Sun, Ningyuan Duan, Xiaobo Jing, Wei Liang, Xing Zhao, Hu Ye, Ling Chen, Qianming Yuan, Quan |
author_facet | Liu, Weiqing Zhou, Liyan Zhou, Chenchen Zhang, Shiwen Jing, Junjun Xie, Liang Sun, Ningyuan Duan, Xiaobo Jing, Wei Liang, Xing Zhao, Hu Ye, Ling Chen, Qianming Yuan, Quan |
author_sort | Liu, Weiqing |
collection | PubMed |
description | Osteoporosis is an age-related disease that affects millions of people. Growth differentiation factor 11 (GDF11) is a secreted member of the transforming growth factor beta (TGF-β) superfamily. Deletion of Gdf11 has been shown to result in a skeletal anterior–posterior patterning disorder. Here we show a role for GDF11 in bone remodelling. GDF11 treatment leads to bone loss in both young and aged mice. GDF11 inhibits osteoblast differentiation and also stimulates RANKL-induced osteoclastogenesis through Smad2/3 and c-Fos-dependent induction of Nfatc1. Injection of GDF11 impairs bone regeneration in mice and blocking GDF11 function prevents oestrogen-deficiency-induced bone loss and ameliorates age-related osteoporosis. Our data demonstrate that GDF11 is a previously unrecognized regulator of bone remodelling and suggest that GDF11 is a potential target for treatment of osteoporosis. |
format | Online Article Text |
id | pubmed-5036163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50361632016-10-04 GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation Liu, Weiqing Zhou, Liyan Zhou, Chenchen Zhang, Shiwen Jing, Junjun Xie, Liang Sun, Ningyuan Duan, Xiaobo Jing, Wei Liang, Xing Zhao, Hu Ye, Ling Chen, Qianming Yuan, Quan Nat Commun Article Osteoporosis is an age-related disease that affects millions of people. Growth differentiation factor 11 (GDF11) is a secreted member of the transforming growth factor beta (TGF-β) superfamily. Deletion of Gdf11 has been shown to result in a skeletal anterior–posterior patterning disorder. Here we show a role for GDF11 in bone remodelling. GDF11 treatment leads to bone loss in both young and aged mice. GDF11 inhibits osteoblast differentiation and also stimulates RANKL-induced osteoclastogenesis through Smad2/3 and c-Fos-dependent induction of Nfatc1. Injection of GDF11 impairs bone regeneration in mice and blocking GDF11 function prevents oestrogen-deficiency-induced bone loss and ameliorates age-related osteoporosis. Our data demonstrate that GDF11 is a previously unrecognized regulator of bone remodelling and suggest that GDF11 is a potential target for treatment of osteoporosis. Nature Publishing Group 2016-09-22 /pmc/articles/PMC5036163/ /pubmed/27653144 http://dx.doi.org/10.1038/ncomms12794 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liu, Weiqing Zhou, Liyan Zhou, Chenchen Zhang, Shiwen Jing, Junjun Xie, Liang Sun, Ningyuan Duan, Xiaobo Jing, Wei Liang, Xing Zhao, Hu Ye, Ling Chen, Qianming Yuan, Quan GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation |
title | GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation |
title_full | GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation |
title_fullStr | GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation |
title_full_unstemmed | GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation |
title_short | GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation |
title_sort | gdf11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036163/ https://www.ncbi.nlm.nih.gov/pubmed/27653144 http://dx.doi.org/10.1038/ncomms12794 |
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