Cargando…

Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs

OBJECTIVES: Rheumatoid arthritis (RA) is characterised by breach of self-tolerance towards citrullinated antigens with generation of anti-citrullinated peptide/proteins antibodies (ACPA). Currently, the nature and source of citrullinated antigens driving the humoral autoimmune response within synovi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Corsiero, Elisa, Bombardieri, Michele, Carlotti, Emanuela, Pratesi, Federico, Robinson, William, Migliorini, Paola, Pitzalis, Costantino
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Basic and Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036240/ https://www.ncbi.nlm.nih.gov/pubmed/26659717 http://dx.doi.org/10.1136/annrheumdis-2015-208356

Ejemplares similares

Characterization of a Synovial B Cell–Derived Recombinant Monoclonal Antibody Targeting Stromal Calreticulin in the Rheumatoid Joints
por: Corsiero, Elisa, et al.
Publicado: (2018)

Accumulation of Self-Reactive Naïve and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome
por: Corsiero, Elisa, et al.
Publicado: (2014)

Ectopic Lymphoid Structures: Powerhouse of Autoimmunity
por: Corsiero, Elisa, et al.
Publicado: (2016)

NETosis as Source of Autoantigens in Rheumatoid Arthritis
por: Corsiero, Elisa, et al.
Publicado: (2016)

Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide
por: Wythe, Sarah E, et al.
Publicado: (2013)

Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression
por: Meednu, Nida, et al.
Publicado: (2022)

Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution
por: Colombo, Federico, et al.
Publicado: (2021)

Expression of citrullin-containing antigens in RA synovium
por: Smeets, TJ, et al.
Publicado: (2001)

Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
por: Rivellese, Felice, et al.
Publicado: (2022)

Citrullination of fibronectin modulates synovial fibroblast behavior
por: Shelef, Miriam A, et al.
Publicado: (2012)

Citrullination of synovial proteins in murine models of rheumatoid arthritis
por: Vossenaar, E, et al.
Publicado: (2003)

Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis
por: El Shikh, Mohey Eldin M., et al.
Publicado: (2022)

Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis
por: Makrygiannakis, Dimitrios, et al.
Publicado: (2012)

Antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis
por: Johansson, Linda, et al.
Publicado: (2016)

Structure and function of an autoantigen, alpha-enloase
por: Moscato, S, et al.
Publicado: (2001)

Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4
por: Shi, Lai, et al.
Publicado: (2021)

Histone citrullination: a new target for tumors
por: Zhu, Dongwei, et al.
Publicado: (2021)

Increased histone citrullination in juvenile idiopathic arthritis
por: Parackova, Zuzana, et al.
Publicado: (2022)

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter
por: Whitehead, Maria A., et al.
Publicado: (2012)

Characterization of Monoclonal Antibodies Recognizing Citrulline-Modified Residues
por: Chen, Yaqiong, et al.
Publicado: (2022)

Carbamylation/citrullination of IgG Fc in bronchiectasis, established RA with bronchiectasis and RA smokers: a potential risk factor for disease
por: Hutchinson, David, et al.
Publicado: (2017)

Pathogenic Role of Circulating Citrullinated Antigens and Anti-Cyclic Monoclonal Citrullinated Peptide Antibodies in Rheumatoid Arthritis
por: Won, Pureun, et al.
Publicado: (2021)

Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins
por: Van Steendam, Katleen, et al.
Publicado: (2010)

Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes?
por: De Rooy, Diederik PC, et al.
Publicado: (2011)

Immunomodulation of RA Patients' PBMC with a Multiepitope Peptide Derived from Citrullinated Autoantigens
por: Gertel, Smadar, et al.
Publicado: (2017)

Platelets derived citrullinated proteins and microparticles are potential autoantibodies ACPA targets in RA patients
por: Xu, Minjie, et al.
Publicado: (2023)

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
por: Amara, Khaled, et al.
Publicado: (2013)

Frequent PD-L1 expression in testicular germ cell tumors
por: Fankhauser, C D, et al.
Publicado: (2015)

Histone deacetylases in RA: epigenetics and epiphenomena
por: Grabiec, Aleksander M, et al.
Publicado: (2010)

Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism
por: Wigerblad, Gustaf, et al.
Publicado: (2016)

Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis
por: Schwenzer, Anja, et al.
Publicado: (2016)

Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure
por: Scirè, Carlo Alberto, et al.
Publicado: (2007)

Retraction: Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
por: Amara, Khaled, et al.
Publicado: (2019)

A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients
por: Nerviani, Alessandra, et al.
Publicado: (2020)

Potential role for PADI-mediated histone citrullination in preimplantation development
por: Kan, Rui, et al.
Publicado: (2012)

Current Challenges and Limitations in Antibody-Based Detection of Citrullinated Histones
por: Neeli, Indira, et al.
Publicado: (2016)

The impact of COVID‐19 on the management of neuroendocrine tumors (NETS): An international NET CONNECT survey of NET patients and healthcare professionals treating net patients
por: Cives, Mauro, et al.
Publicado: (2022)

The development and characterisation of porphyrin isothiocyanate–monoclonal antibody conjugates for photoimmunotherapy
por: Hudson, R, et al.
Publicado: (2005)

Can Synovial Pathobiology Integrate with Current Clinical and Imaging Prediction Models to Achieve Personalized Health Care in Rheumatoid Arthritis?
por: Humby, Frances Claire, et al.
Publicado: (2017)

In vivo selection of synovial specific targets using phage display technology
por: Pitzalis, C
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_oletd5vfukj2teslaqospphtju